Protein Domain : IPR017758

Type:  Family Name:  Coenzyme A disulphide reductase
Description:  Coenzyme A disulphide reductase () has been characterised in Staphylococcus aureus, Pyrococcus horikoshii, and Borrelia burgdorferi(Lyme disease spirochete), and inferred in several other species on the basis of high levels of CoA and an absence of glutathione as a protective thiol. Coenzyme A disulphide reductase specifically catalyses the NAD(P)H-dependent reduction of coenzyme A disulphide using FAD and NAD(P)H. In some species the enzymes show a distinct preference for NADH or NADPH, while others can use either substrate equally well. The reduction of disulphides occurs by a thiol-disulphide exchange reaction, but involves only a single catalytic cysteine residue that forms a stable mixed disulphide with CoA during catalysis. This enzyme contains 2 FAD binding domains and a single NAD(P)H binding domain []. Short Name:  CoA_disulphide_reductase
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1 Child Features

DB identifier Type Name
IPR023536 Family Coenzyme A disulphide reductase, staphyolococci

1 Contains

DB identifier Type Name
IPR004099 Domain Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

1 Cross References

Identifier
TIGR03385

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0003756 IPR017758
GO:0050451 IPR017758
GO:0050660 IPR017758
GO:0050661 IPR017758
GO:0055114 IPR017758

5 Ontology Annotations

GO Term Gene Name
GO:0003756 IPR017758
GO:0050451 IPR017758
GO:0050660 IPR017758
GO:0050661 IPR017758
GO:0055114 IPR017758

0 Parent Features

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            18399646