Protein Domain : IPR029324

Type:  Domain Name:  Mitochondrial apoptosis-inducing factor, C-terminal domain
Description:  This C-terminal domain appears to be a dimerisation domain of the mitochondrial apoptosis-inducing factor 1 protein. The domain also appears at the C terminus of FAD-dependent pyridine nucleotide-disulfide oxidoreductases. Apoptosis inducing factor (AIF) is a bifunctional mitochondrial flavoprotein critical for energy metabolism and induction of caspase-independent apoptosis []. On reduction with NADH, AIF undergoes dimerisation and forms tight, long-lived FADH2-NAD charge-transfer complexes proposed to be functionally important []. Short Name:  AIF_C
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0 Child Features

0 Contains

1 Cross References

Identifier
PF14721

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0046983 IPR029324

1 Ontology Annotations

GO Term Gene Name
GO:0046983 IPR029324

1 Parent Features

DB identifier Type Name
IPR004099 Domain Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            19447115
            10913597