Protein Domain : IPR030322

Type:  Family Name:  Plasma membrane calcium-transporting ATPase 2
Description:  Plasma membrane calcium-transporting ATPase 2 (ATP2B2, also known as PMCA2) belongs to the IIB subfamily of P-type ATPases, whose members are plasma membrane Ca2+ ATPases (PMCAs) that catalyse the hydrolysis of ATP coupled with the transport of calcium []. ATP2B2 has very high calmodulin affinity, however, it is only poorly stimulated by calmodulin [].ATP2B2 is expressed in the developing nervous system, adult cerebellar neurons, uterus, liver, and kidney []. Interestingly, it is expressed in the mammary gland, where it has a role in the enrichment of Ca2+ in milk [, ]. It is also expressed in the hair cells of the Corti organ of the inner ear, and acts as a regulator of the dendritic calcium equilibrium controlling Purkinje cell dendritic growth in brains []. In mice, mutations in the ATP2B2 gene cause deafness [] and cerebellar ataxia []. In the retina, it regulates the homeostasis of Ca2+ which controls the transmission of visual signals to the synapses []. Therefore, mutations in the ATP2B2 gene also cause defective synaptic signalling within rod cells []. ATP2B2 has also been linked to the progression of breast cancer []. Short Name:  ATP2B2
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR24093:SF247

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0005388 IPR030322
GO:0005524 IPR030322
GO:0070588 IPR030322
GO:0016021 IPR030322

4 Ontology Annotations

GO Term Gene Name
GO:0005388 IPR030322
GO:0005524 IPR030322
GO:0070588 IPR030322
GO:0016021 IPR030322

1 Parent Features

DB identifier Type Name
IPR006408 Family P-type ATPase, subfamily IIB

0 Proteins

8 Publications

First Author Title Year Journal Volume Pages PubMed ID
            23041476
            16675132
            15302868
            22047666
            24288624
            21232211
            16822977
            20534448