Protein Domain : IPR030319

Type:  Family Name:  Plasma membrane calcium-transporting ATPase 4
Description:  ATP2B4 (also known as PMCA4) belongs to the IIB subfamily of P-type ATPases, whose members are plasma membrane Ca2+ ATPases (PMCAs) that catalyse the hydrolysis of ATP coupled with the transport of calcium []. ATP2B4 is is expressed at high levels in numerous tissues/cell types, including the brain, the heart, and the spermatozoa []. The C-terminal of ATP2B4 interacts with the PDZ domains of a number of partner proteins, including neuronal nitric-oxide synthase (nNOS) []. The interaction between ATP2B4 and neuronal nitric-oxide synthase regulates cardiac contractility through modulation of a compartmentalised cyclic nucleotide microdomain []. ATP2B4 is highly concentrated in the spermatozoon head and is involved in the fertilisation process []. It also has a role in colon cancer tumourigenesis []. Short Name:  ATP2B4
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR24093:SF276

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0005388 IPR030319
GO:0005524 IPR030319
GO:0070588 IPR030319
GO:0016021 IPR030319

4 Ontology Annotations

GO Term Gene Name
GO:0005388 IPR030319
GO:0005524 IPR030319
GO:0070588 IPR030319
GO:0016021 IPR030319

1 Parent Features

DB identifier Type Name
IPR006408 Family P-type ATPase, subfamily IIB

0 Proteins

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            23041476
            11591728
            24570005
            21965681
            17433436