Type: | Family | Name: | Pyrophosphatase PpaX |
Description: | Microorganisms that can utilise halogenated compounds as growth substrates produce enzymes that cleave carbon-halogen bonds and are commonly calleddehalogenases. The hydrolytic dehalogenases catalyse a nucleophilic displacement reaction, with water as the sole co-substrate []. They aredivided into haloalkane dehalogenases and haloacid dehalogenases (HAD). HADs belong to a large superfamily of hydrolases with diverse substratespecificity, which also includes epoxide hydrolases, phosphoglycolate phosphatases, histidinol phosphate phosphatases, nitrophenyl phosphatasesand numerous other proteins []. This entry represents the pyrophosphatase PpaX subfamily of the HAD superfamily. These enzymes hydrolyse pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK/P []. They may play a role in controlling the intracellular pyrophosphate pool. | Short Name: | Pyrophosphatase_Ppax |