Protein Domain : IPR016255

Type:  Family Name:  Serine/threonine-protein kinase, GCN2
Description:  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].This entry represents serine/threonine-protein kinases (), such as GCN2. GCN2 regulates the G1/S cell cycle checkpoint in response to DNA damage [, ]. It stimulates GCN4 translation in amino acid-starved cells by phosphorylating the alpha subunit of eIF-2 (SUI2) on 'Ser-52' []. Short Name:  Ser/Thr_kinase_GCN2
Paste the following link

0 Child Features

3 Contains

DB identifier Type Name
IPR006575 Domain RWD domain
IPR017441 Binding_site Protein kinase, ATP binding site
IPR008271 Active_site Serine/threonine-protein kinase, active site

1 Cross References

Identifier
PIRSF000660

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0004674 IPR016255
GO:0005524 IPR016255
GO:0042803 IPR016255
GO:0006446 IPR016255
GO:0006468 IPR016255

5 Ontology Annotations

GO Term Gene Name
GO:0004674 IPR016255
GO:0005524 IPR016255
GO:0042803 IPR016255
GO:0006446 IPR016255
GO:0006468 IPR016255

0 Parent Features

0 Proteins

8 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3291115
            12368087
            12471243
            15078142
            15320712
            17890903
            17369398
            11350982