Protein Domain : IPR030363

Type:  Family Name:  Phospholipid-transporting ATPase IG
Description:  Phospholipid-transporting ATPase IG (also known as ATP11C) belongs to subfamily IV of the P-type ATPases (P4-ATPase) family, whose members transport phospholipids across the membrane. ATP11C is ubiquitously expressed and binds CDC50A as its beta-subunit []. In mice, ATP11C plays an important role in the proper development of B-cell lymphocytes [, , ]. In human cells, ATP11C can function as a phosphatidylserine (PtdSer) flippase at the plasma membrane. During apoptosis, the inactivation of ATP11C is required for cells to expose and display apoptotic PtdSer, which then serves as an "eat me" signal for macrophages to engulf the cells []. Short Name:  ATP11C
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR24092:SF38

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004012 IPR030363
GO:0005524 IPR030363
GO:0045332 IPR030363
GO:0016021 IPR030363

4 Ontology Annotations

GO Term Gene Name
GO:0004012 IPR030363
GO:0005524 IPR030363
GO:0045332 IPR030363
GO:0016021 IPR030363

1 Parent Features

DB identifier Type Name
IPR006539 Family P-type ATPase, subfamily IV

0 Proteins

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            23103747
            21423173
            21423172
            24904167
            24898253