Protein Domain : IPR030346

Type:  Family Name:  Phospholipid-transporting ATPase IC
Description:  Phospholipid-transporting ATPase IC (also known as ATP8B1 or ATPIC) belongs to subfamily IV of the P-type ATPases family, whose members transport phospholipids across the membrane. ATP8B1 can bind either CDC50A or CDC50B as its accessory protein for endoplasmic reticulum exit and plasma membrane lipid flippase activity [, , ].In hepatocytes, ATP8B1 localises in the canalicular membrane, where it may maintain the membrane integrity and to the function of ABCB4, an ABC floppase that play a role in bile export []. In the epithelial Caco-2 cells, ATP8B1 is required for apical protein expression and microvillus formation in polarised epithelial cells []. Mutations in ATP8B1 cause two forms of intrahepatic cholestasis, progressive familial intraheptic cholestasis (PFIC) and benign recurrent intrahepatic cholestasis (BFIC) []. Short Name:  ATP8B1
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR24092:SF48

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004012 IPR030346
GO:0005524 IPR030346
GO:0015914 IPR030346
GO:0016021 IPR030346

4 Ontology Annotations

GO Term Gene Name
GO:0004012 IPR030346
GO:0005524 IPR030346
GO:0015914 IPR030346
GO:0016021 IPR030346

1 Parent Features

DB identifier Type Name
IPR006539 Family P-type ATPase, subfamily IV

0 Proteins

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            21820390
            9500542
            20512993
            17948906
            20961850
            20947505