Protein Domain : IPR030342

Type:  Family Name:  Phospholipid-transporting ATPase IA
Description:  Phospholipid-transporting ATPase IA (also known as ATP8A1 or ATPIA) belongs to subfamily IV of the P-type ATPases family, whose members transport phospholipids across the membrane. ATP8A1 and the CDC50 family proteins form a complex that mediates the translocation of aminophospholipids such as phosphatidylserine (PS) and phosphatidylethanolamine (PE) from the outer to inner leaflets of the plasma membrane []. This complex plays a major role in cell migration []. ATP8A1 plays a role in lipid asymmetry and vesicle trafficking []. In mice, mutations in the ATP8A1 gene is associated with phosphatidylserine externalisation in hippocampus and delayed hippocampus-dependent learning []. Short Name:  ATP8A1
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR24092:SF56

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004012 IPR030342
GO:0005524 IPR030342
GO:0015914 IPR030342
GO:0016021 IPR030342

4 Ontology Annotations

GO Term Gene Name
GO:0004012 IPR030342
GO:0005524 IPR030342
GO:0015914 IPR030342
GO:0016021 IPR030342

1 Parent Features

DB identifier Type Name
IPR006539 Family P-type ATPase, subfamily IV

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            23103747
            22007859
            23269685