Protein Domain : IPR010911

Type:  Domain Name:  Rab-binding domain
Description:  This entry represents the Rab-binding domain.Rab are small GTPases implicated in vesicle trafficking. Like the other small GTPases, Rab proteins act as molecular switches, with an active GTP-bound formthat interacts with its target or effector protein and an inactive GDP-bound form. A subgroup of Rab effectors contain in their N-terminal part a conservedregion of around 70 amino acid residues, the Rab-binding domain (RabBD). In some Rab effector domains an atypical FYVE-type zinc finger is inserted in thecentral part [].The crystal structure of the Rab effector domain of Rabphilin-3A in complex with Rab3A has been solved []. The structure consists of twolong helices separated by an atypical FYVE-type zinc finger which adopts a conformation similar to classical ones. The central zincfinger does not directly interact with Rab3A. The amino acids important for this interaction are located around a short C-terminal motif (SGAWFF) and anacidic cluster in the N-terminal area. Short Name:  Rab_BD
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0 Child Features

0 Contains

1 Cross References

Identifier
PS50916

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0017137 IPR010911
GO:0006886 IPR010911

2 Ontology Annotations

GO Term Gene Name
GO:0017137 IPR010911
GO:0006886 IPR010911

1 Parent Features

DB identifier Type Name
IPR011011 Domain Zinc finger, FYVE/PHD-type

9 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
CiLak.02G009600.1.p PAC:44285490 Carya illinoinensis Lakota 2467  
CiEll.02G005000.3.p PAC:44339522 Carya illinoinensis Elliott 2446  
CiEll.02G005000.2.p PAC:44339521 Carya illinoinensis Elliott 2478  
CiEll.02G005000.1.p PAC:44339520 Carya illinoinensis Elliott 2478  
Caril.02G009400.2.p PAC:45037073 Carya illinoinensis 2478  
Caril.02G009400.3.p PAC:45037074 Carya illinoinensis 2446  
Caril.02G009400.1.p PAC:45037072 Carya illinoinensis 2478  
CiPaw.02G008700.2.p PAC:45846601 Carya illinoinensis Pawnee 2440  
CiPaw.02G008700.1.p PAC:45846600 Carya illinoinensis Pawnee 2478  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10025402
            12578829