Protein Domain : IPR016243

Type:  Family Name:  Tyrosine-protein kinase, CSF-1/PDGF receptor family
Description:  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Tyrosine-protein kinases can transfer a phosphate group from ATP to a tyrosine residue in a protein. These enzymes can be divided into two main groups []:Receptor tyrosine kinases (RTK), which are transmembrane proteins involved in signal transduction; they play key roles in growth, differentiation, metabolism, adhesion, motility, death and oncogenesis []. RTKs are composed of 3 domains: an extracellular domain (binds ligand), a transmembrane (TM) domain, and an intracellular catalytic domain (phosphorylates substrate). The TM domain plays an important role in the dimerisation process necessary for signal transduction []. Cytoplasmic / non-receptor tyrosine kinases, which act as regulatory proteins, playing key roles in cell differentiation, motility, proliferation, and survival. For example, the Src-family of protein-tyrosine kinases [].This group represents a tyrosine-protein kinase, CSF-1/PDGF receptor type. Short Name:  Tyr_kinase_CSF1/PDGF_rcpt

5 Child Features

DB identifier Type Name
IPR027290 Family Platelet-derived growth factor receptor alpha
IPR027288 Family Platelet-derived growth factor receptor beta
IPR027263 Family Mast/stem cell growth factor receptor
IPR030118 Family Receptor-type tyrosine-protein kinase FLT3
IPR030658 Family Macrophage colony-stimulating factor 1 receptor

12 Contains

DB identifier Type Name
IPR000719 Domain Protein kinase domain
IPR011009 Domain Protein kinase-like domain
IPR020635 Domain Tyrosine-protein kinase, catalytic domain
IPR001245 Domain Serine-threonine/tyrosine-protein kinase catalytic domain
IPR013783 Domain Immunoglobulin-like fold
IPR007110 Domain Immunoglobulin-like domain
IPR003599 Domain Immunoglobulin subtype
IPR013098 Domain Immunoglobulin I-set
IPR003598 Domain Immunoglobulin subtype 2
IPR017441 Binding_site Protein kinase, ATP binding site
IPR001824 Conserved_site Tyrosine-protein kinase, receptor class III, conserved site
IPR008266 Active_site Tyrosine-protein kinase, active site

1 Cross References

Identifier
PIRSF000615

0 Found In

2 GO Annotations

GO Term Gene Name Organism
GO:0004714 IPR016243
GO:0007169 IPR016243

0 Parent Features

6 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Spipo8G0033000 PAC:31511612 Spirodela polyrhiza 273  
Traes_7DS_3E371DD9A.3 PAC:31796951 Triticum aestivum 268  
HORVU5Hr1G056920.7 PAC:38456153 Hordeum vulgare 269  
HORVU5Hr1G056920.5 PAC:38456152 Hordeum vulgare 269  
HORVU5Hr1G056920.4 PAC:38456151 Hordeum vulgare 269  
HORVU5Hr1G056920.6 PAC:38456150 Hordeum vulgare 269  

8 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3291115
            12368087
            12471243
            15078142
            15320712
            19275641
            16700535
            15845350