Protein Domain : IPR003159

Type:  Domain Name:  Polysaccharide lyase family 8, central domain
Description:  Proteins containing this central domain consist of a group of secreted bacterial lyase enzymes capable of acting on a variety of substrates. One such enzyme is hyaluronate lyase, a Streptococcal surface enzyme that degrades hyaluronan and chondroitin, thereby helping to spread the bacteria throughout host tissues []. Hyaluronate lyase () is a four-domain enzyme containing an N-terminal carbohydrate-binding domain, a spacer domain, a catalytic domain, and a C-terminal domain that modulates access to the catalytic cleft of the enzyme. The central domain has a beta-sandwich topology, with 18 strands in two sheets. Other bacterial enzymes that display this structure include the central domain of chondroitin AC lyase () [], the central domain of xanthan lyase () [], and the third domain of chondroitin ABC lyase () []. This entry represents these domains of hyaluronate lyase, chondroitin AC lyase, xanthan lyase and chondroitin ABC lyase. This domain if almost always associated with the polysaccharide lyase family 8 C-terminal domain (). Short Name:  Lyase_8_central_dom
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0 Child Features

0 Contains

1 Cross References

Identifier
PF02278

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0016829 IPR003159
GO:0005576 IPR003159

2 Ontology Annotations

GO Term Gene Name
GO:0016829 IPR003159
GO:0005576 IPR003159

1 Parent Features

DB identifier Type Name
IPR014718 Domain Glycoside hydrolase-type carbohydrate-binding, subgroup

2 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
58439.m000009 B9TLN7 PAC:16829146 Ricinus communis 269  
57697 C1E3I8 PAC:27400495 Micromonas sp RCC299 1539  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            14523022
            10329169
            12706721
            12475987