Protein Domain : IPR012318

Type:  Domain Name:  Crp-type HTH domain
Description:  The Crp-type HTH domain is a DNA-binding, winged helix-turn-helix (wHTH) domain of about 70-75 amino acids present in transcription regulators of thecrp-fnr family, involved in the control of virulence factors, enzymes of aromatic ring degradation, nitrogen fixation, photosynthesis, and varioustypes of respiration. The Crp-Fnr family is named after the first members identified in Escherichia coli: the well characterised cyclic AMP receptor protein CRP or CAP (catabolite activator protein) and the fumarate and nitrate reductaseregulator Fnr. Crp-type HTH domain proteins occur in most bacteria and in chloroplasts of red algae. The DNA-binding HTH domain is located in theC-terminal part; the N-terminal part of the proteins of the Crp-Fnr family contains a nucleotide-binding domain and adimerization/linker helix occurs in between. The Crp-Fnr regulators predominantly act as transcription activators, but can also be importantrepressors, and respond to diverse intracellular and exogenous signals, such as cAMP, anoxia, redox state, oxidative and nitrosative stress, carbonmonoxide, nitric oxide or temperature [, ]. Short Name:  HTH_CRP
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0 Child Features

1 Contains

DB identifier Type Name
IPR018335 Conserved_site Transcription regulator HTH, Crp-type, conserved site

4 Cross Referencess

Identifier
PF00325
PR00034
PS51063
SM00419

1 Found In

DB identifier Type Name
IPR022299 Family Transcription regulator, NtcA

2 GO Annotations

GO Term Gene Name
GO:0003677 IPR012318
GO:0006355 IPR012318

2 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR012318
GO:0006355 IPR012318

1 Parent Features

DB identifier Type Name
IPR011991 Domain Winged helix-turn-helix DNA-binding domain

6 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
57574.m000038 B9TKK1 PAC:16829060 Ricinus communis 123  
Pp3s34_690V3.1.p PAC:32948282 Physcomitrium patens 226  
Pp3s34_240V3.1.p PAC:32948249 Physcomitrium patens 230  
Pp3s92_50V3.1.p PAC:32963381 Physcomitrium patens 713  
Brdisv1pangenome1010518m.p PAC:33641011 Brachypodium distachyon Pangenome 607  
Brdisv1BdTR11A1040909m.p PAC:35691646 Brachypodium distachyon BdTR11a 607  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            14638413
            8441692