Protein Domain : IPR000045

Type:  Domain Name:  Prepilin type IV endopeptidase, peptidase domain
Description:  This group of aspartic endopeptidases belong to MEROPS peptidase family A24 (type IV prepilin peptidase family, clan AD), subfamily A24A.Bacteria produce a number of protein precursors that undergo post-translational methylation and proteolysis prior to secretion as active proteins. Type IV prepilin leader peptidases are enzymes that mediate this type of post-translational modification. Type IV pilin is a protein found on the surface of Pseudomonas aeruginosa, Neisseria gonorrhoeaeand other Gram-negative pathogens. Pilin subunits attach the infecting organism to the surface ofhost epithelial cells. They are synthesised as prepilin subunits, which differ from mature pilin by virtue of containing a 6-8 residue leaderpeptide consisting of charged amino acids. Mature type IV pilins also contain a methylated N-terminal phenylalanine residue.The bifunctional enzyme prepilin peptidase (PilD) from Pseudomonas aeruginosais a key determinant in both type-IV pilus biogenesis and extracellular protein secretion, in its roles as a leader peptidase and methyl transferase (MTase). It is responsible for endopeptidic cleavage of the unique leader peptides that characterise type-IV pilin precursors, as well as proteins with homologous leader sequences that are essential components of the general secretion pathway found in a variety of Gram-negative pathogens. Following removal of the leader peptides, the same enzyme is responsible for the second posttranslational modification that characterises the type-IV pilins and their homologues, namely N-methylation of the newly exposed N-terminal amino acid residue []. This entry represents the peptidase domain from the prepilin type IV endopeptidases []. It can be found on its own, or in the case of the bifunctional enzymes, next to a methylation domain. Short Name:  Prepilin_IV_endopep_pep
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0 Child Features

0 Contains

1 Cross References

Identifier
PF01478

1 Found In

DB identifier Type Name
IPR014032 Family Peptidase A24A, prepilin type IV, bacterial

2 GO Annotations

GO Term Gene Name
GO:0004190 IPR000045
GO:0016020 IPR000045

2 Ontology Annotations

GO Term Gene Name
GO:0004190 IPR000045
GO:0016020 IPR000045

0 Parent Features

6 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
32299.m000024 B9TEV6 PAC:16825375 Ricinus communis 169  
Solyc00g134820.1.1 PAC:36128415 Solanum lycopersicum 249  
Myper.0063s0726.1.p PAC:39113694 Myagrum perfoliatum 166  
Solyc00g134820.1.1 PAC:41467405 Solanum lycopersicum 249  
Myper.0002s1686.1.p PAC:45611296 Myagrum perfoliatum 185  
Zosma07g00130 PAC:50101973 Zostera marina 776  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10625704
            9224881