Protein Domain : IPR005189

Type:  Domain Name:  Focal adhesion kinase, targeting (FAT) domain
Description:  Focal adhesion kinase (FAK) is a tyrosine kinase found in focal adhesions, intracellular signalling complexes that are formed following engagement of the extracellular matrix by integrins. The C-terminal "focal adhesion targeting" (FAT) region is necessary and sufficient for localizing FAK to focal adhesions. The crystal structure of FAT shows it forms a four-helix bundle that resembles those found in two other proteins involved in cell adhesion, alpha-catenin and vinculin []. The binding of FAT to the focal adhesion protein, paxillin, requires the integrity of the helical bundle, whereas binding to another focal adhesion protein, talin, does not. Short Name:  Focal_adhesion_kin_target_dom
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0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF03623
PD006413
SSF68993

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0004713 IPR005189
GO:0004871 IPR005189
GO:0006468 IPR005189
GO:0007172 IPR005189
GO:0005925 IPR005189

5 Ontology Annotations

GO Term Gene Name
GO:0004713 IPR005189
GO:0004871 IPR005189
GO:0006468 IPR005189
GO:0007172 IPR005189
GO:0005925 IPR005189

0 Parent Features

60 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
31120.m000026 B9TIM4 PAC:16824823 Ricinus communis 167  
Gorai.006G232500.2 A0A0D2S169 PAC:26829277 Gossypium raimondii 626  
Gorai.006G232500.3 A0A0D2QFL9 PAC:26829276 Gossypium raimondii 652  
Gorai.006G232500.1 A0A0D2QFL9 PAC:26829275 Gossypium raimondii 652  
Gorai.011G072100.3 A0A0D2RI83 PAC:26810853 Gossypium raimondii 628  
Gorai.011G133900.2 A0A0D2T7H7 PAC:26808910 Gossypium raimondii 635  
Gorai.011G072100.2 A0A0D2VJE2 PAC:26810854 Gossypium raimondii 602  
Gorai.011G133900.1 A0A0D2T7H7 PAC:26808911 Gossypium raimondii 635  
Aco025370.1 PAC:33028002 Ananas comosus 163  
AL4G17430.t1 PAC:35923611 Arabidopsis lyrata 674  
DCAR_010818 PAC:36069351 Daucus carota 70  
Phvul.002G193400.2.p PAC:37177377 Phaseolus vulgaris 330  
Phvul.002G193400.1.p PAC:37177376 Phaseolus vulgaris 331  
evm.model.Scaffold_629.97 PAC:37860027 Coffea arabica 116  
Gohir.D10G121800.1.p PAC:38114265 Gossypium hirsutum 635  
Gohir.D10G121800.2.p PAC:38114266 Gossypium hirsutum 635  
Gohir.D09G212700.1.p PAC:38125963 Gossypium hirsutum 652  
Mamar.0018s0184.1.p PAC:39432734 Malcolmia maritima 159  
Mamar.0045s0083.1.p PAC:39423309 Malcolmia maritima 159  
Mamar.0029s0757.1.p PAC:39439038 Malcolmia maritima 159  
Eruve.4137s0002.1.p PAC:39894723 Eruca vesicaria 116  
Eruve.4799s0003.1.p PAC:39883928 Eruca vesicaria 116  
Distr.0233s0027.1.p PAC:40033313 Diptychocarpus strictus 716  
HanXRQChr01g0023221 A0A251VR52 PAC:40324388 Helianthus annuus 123  
Manes.02G154101.1.p PAC:41880153 Manihot esculenta 215  
Gomus.D09G238000.1.p A0A5D2TQJ7 PAC:42097071 Gossypium mustelinum 652  
Gomus.A09G229100.1.p A0A5D2Y145 PAC:42121246 Gossypium mustelinum 606  
Gomus.D10G137100.1.p A0A5D2T6I7 PAC:42115306 Gossypium mustelinum 634  
Gomus.D10G075100.1.p A0A5D2T521 PAC:42117041 Gossypium mustelinum 727  
Gotom.D09G246500.2.p A0A5D2JMH8 PAC:42234210 Gossypium tomentosum 652  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11799401