Protein Domain : IPR013249

Type:  Domain Name:  RNA polymerase sigma factor 70, region 4 type 2
Description:  The bacterial core RNA polymerase complex, which consists of five subunits, is sufficient for transcription elongation and termination but is unable to initiate transcription. Transcription initiation from promoter elements requires a sixth, dissociable subunit called a sigma factor, which reversibly associates with the core RNA polymerase complex to form a holoenzyme []. RNA polymerase recruits alternative sigma factors as a means of switching on specific regulons. Most bacteria express a multiplicity of sigma factors. Two of these factors, sigma-70 (gene rpoD), generally known as the major or primary sigma factor, and sigma-54 (gene rpoN or ntrA) direct the transcription of a wide variety of genes. The other sigma factors, known as alternative sigma factors, are required for the transcription of specific subsets of genes.With regard to sequence similarity, sigma factors can be grouped into two classes, the sigma-54 and sigma-70 families. Sequence alignments of the sigma70 family members reveal four conserved regions that can be further divided into subregions eg. sub-region 2.2, which may be involved in the binding of the sigma factor to the core RNA polymerase; and sub-region 4.2, which seems to harbor a DNA-binding 'helix-turn-helix' motif involved in binding the conserved -35 region of promoters recognised by the major sigma factors [, ]. Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 promoter element via a helix-turn-helix motif []. Short Name:  RNA_pol_sigma70_r4_t2
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0 Child Features

0 Contains

1 Cross References

Identifier
PF08281

17 Found Ins

DB identifier Type Name
IPR016371 Family RNA polymerase sigma-H factor
IPR014218 Family RNA polymerase sigma-H type
IPR014305 Family RNA polymerase sigma-G type, actinobacteria
IPR014327 Family RNA polymerase sigma-70, Bacteroidetes type
IPR014325 Family RNA polymerase sigma-E factor, actinobacteria
IPR014326 Family RNA polymerase sigma-70 factor, Planctomycetaceae
IPR014331 Family RNA polymerase sigma-70 ECF-like, Rhodopirellula baltica
IPR014303 Family RNA polymerase sigma-70, ECF type
IPR014304 Family RNA polymerase sigma-Z type
IPR017622 Family Transcription regulator, P21/BotR , Clostridium toxin-associated
IPR014286 Family RNA polymerase sigma-70 RpoE type
IPR014293 Family RNA polymerase sigma-70, actinobacteria
IPR014294 Family RNA polymerase sigma-W, bacillaceae
IPR011745 Family RNA polymerase sigma-70, Myxococcus xanthus
IPR014289 Family RNA polymerase sigma-24-related
IPR014296 Family RNA polymerase sigma-M, bacillaceae
IPR014298 Family RNA polymerase sigma-X type

5 GO Annotations

GO Term Gene Name
GO:0003677 IPR013249
GO:0003700 IPR013249
GO:0016987 IPR013249
GO:0006352 IPR013249
GO:0006355 IPR013249

5 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR013249
GO:0003700 IPR013249
GO:0016987 IPR013249
GO:0006352 IPR013249
GO:0006355 IPR013249

1 Parent Features

DB identifier Type Name
IPR013324 Domain RNA polymerase sigma factor, region 3/4

14 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
30892.m000027 B9TKG6 PAC:16824679 Ricinus communis 190  
32775.m000024 B9TEC6 PAC:16825552 Ricinus communis 271  
34613.m000038 B9TJU4 PAC:16826284 Ricinus communis 139  
36669.m000026 B9TNB3 PAC:16826954 Ricinus communis 75  
44451.m000025 B9TIA7 PAC:16827700 Ricinus communis 68  
28920.m000046 PAC:16801985 Ricinus communis 169  
Pp3s30_1150V3.1.p PAC:32948486 Physcomitrium patens 434  
Pp3s32_300V3.1.p PAC:32948399 Physcomitrium patens 593  
Brdisv1pangenome1008435m.p PAC:33623694 Brachypodium distachyon Pangenome 427  
Brdisv1pangenome1010066m.p PAC:33655719 Brachypodium distachyon Pangenome 593  
Brdisv1pangenome1010958m.p PAC:33623458 Brachypodium distachyon Pangenome 575  
Brdisv1BdTR11A1049085m.p PAC:35692669 Brachypodium distachyon BdTR11a 868  
Brdisv1BdTR11A1040341m.p PAC:35695433 Brachypodium distachyon BdTR11a 482  
Brdisv1BdTR11A1040413m.p PAC:35694620 Brachypodium distachyon BdTR11a 2308  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3052291
            1597408
            3092189
            11931761