Protein Domain : IPR001980

Type:  Family Name:  Coenzyme A biosynthesis protein
Description:  Temperature-sensitive mutants of Escherichia coli, defective in the transfer of 3-deoxy-D-manno-octulosonic acid (KDO) from CMP-KDO to a tetraacyldisaccharide 1,4'-bisphosphate precursor of lipid A, have been used to map KDO transferase activity on the E. coli chromosome []. The KDO transferase gene, designated kdtA, was shown to code for a 43kDa polypeptide. Overexpression of this single gene product greatly stimulates incorporation of two stereochemically distinct KDO residues during lipopolysaccharide biosynthesis in extracts of E. coli [].From these experiments this protein was thought to play a role in lipopolysaccharide biosynthesis, however now it is annotated as phosphopantetheine adenylyltransferase (), which catalyses the reversible transfer of an adenylyl group from ATP to 4'-phosphopantetheine to give dephospho-CoA (DPCOA) and pyrophosphate in the fourth (and penultimate) step of coenzyme A biosynthesis []. Short Name:  LPS_biosynth
Paste the following link

0 Child Features

1 Contains

DB identifier Type Name
IPR004821 Domain Cytidyltransferase-like domain

3 Cross Referencess

Identifier
PR01020
TIGR01510
MF_00151

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0004595 IPR001980
GO:0015937 IPR001980

2 Ontology Annotations

GO Term Gene Name
GO:0004595 IPR001980
GO:0015937 IPR001980

0 Parent Features

1 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
28069.m000038 B9TCE9 PAC:16799857 Ricinus communis 162  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2033061
            10480925