Protein Domain : IPR000081

Type:  Domain Name:  Peptidase C3, picornavirus core protein 2A
Description:  Cysteine peptidases have characteristic molecular topologies, which can be seen not only in their three-dimensional structures, but commonly also in the two-dimensional structures. These are peptidases in which the nucleophile is the sulphydryl group of a cysteine residue. Cysteine proteases are divided into clans (proteins which are evolutionary related), and further sub-divided into families, on the basis of the architecture of their catalytic dyad or triad []. This domain defines cysteine peptidases belong to MEROPS peptidase family C3 (picornain, clan PA(C)), subfamilies 3CA and 3CB. The protein fold of this peptidase domain for members of this family resembles that of the serine peptidase, chymotrypsin [], the type example for clan PA.Picornaviral proteins are expressed as a single polyprotein which is cleaved by the viral 3C cysteine protease []. The poliovirus polyprotein is selectively cleaved between the Gln-|-Gly bond. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly. Short Name:  Peptidase_C3
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PF00947
PD001306

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0008233 IPR000081
GO:0006508 IPR000081
GO:0016032 IPR000081

3 Ontology Annotations

GO Term Gene Name
GO:0008233 IPR000081
GO:0006508 IPR000081
GO:0016032 IPR000081

0 Parent Features

2 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Ibeam.2097s0010.1.p PAC:39788248 Iberis amara 505  
HanXRQChr16g0502581 A0A251S0M0 PAC:40300366 Helianthus annuus 855  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9460917
            8164744
            11517925