Protein Domain : IPR002306

Type:  Family Name:  Tryptophan-tRNA ligase
Description:  This entry represents tryptophan-tRNA lgiase (also known as tryptophanyl-tRNA synthetase) (). The enzyme is widely distributed, being found in archaea, bacteria and eukaryotes. The crystal structure of tryptophan-tRNA ligase has been solved [].The class Ia aminoacyl-tRNA synthetases consist of the isoleucyl, methionyl, valyl, leucyl, cysteinyl, and arginyl-tRNA synthetases; the class Ib include the glutamyl and glutaminyl-tRNA synthetases, and the class Ic are the tyrosyl and tryptophanyl-tRNA synthetases[].The aminoacyl-tRNA synthetase (also known as aminoacyl-tRNA ligase) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These proteins differ widely in size and oligomeric state, and have limited sequence homology []. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric []. Class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet fold flanked by alpha-helices [], and are mostly dimeric or multimeric, containing at least three conserved regions [, , ]. However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c. Short Name:  Trp-tRNA-ligase

2 Child Features

DB identifier Type Name
IPR020653 Family Tryptophan-tRNA ligase, archaea
IPR024109 Family Tryptophan-tRNA ligase, bacterial-type

2 Contains

DB identifier Type Name
IPR014729 Domain Rossmann-like alpha/beta/alpha sandwich fold
IPR001412 Conserved_site Aminoacyl-tRNA synthetase, class I, conserved site

3 Cross Referencess


0 Found In

5 GO Annotations

GO Term Gene Name Organism
GO:0000166 IPR002306
GO:0004830 IPR002306
GO:0005524 IPR002306
GO:0006436 IPR002306
GO:0005737 IPR002306

1 Parent Features

DB identifier Type Name
IPR002305 Family Aminoacyl-tRNA synthetase, class Ic

514 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
411225 D8RGZ1 PAC:15406944 Selaginella moellendorffii 298  
92189 D8RFW4 PAC:15416236 Selaginella moellendorffii 358  
442375 D8RSX9 PAC:15410132 Selaginella moellendorffii 390  
130546 D8T2H1 PAC:15422603 Selaginella moellendorffii 333  
evm.model.supercontig_1142.2 PAC:16406167 Carica papaya 317  
evm.model.supercontig_7.214 PAC:16425125 Carica papaya 418  
29708.m000188 B9SW26 PAC:16806376 Ricinus communis 405  
29794.m003408 B9RS09 PAC:16808767 Ricinus communis 412  
Cucsa.174080.1 PAC:16966647 Cucumis sativus 303  
Cucsa.312470.1 PAC:16976847 Cucumis sativus 455  
Cucsa.312470.2 A0A0A0LEU9 PAC:16976848 Cucumis sativus 414  
GSVIVT01020576001 E0CTG2 PAC:17829902 Vitis vinifera 399  
GSVIVT01035293001 D7STH1 PAC:17840469 Vitis vinifera 416  
orange1.1g022791m A0A067GX25 PAC:18096646 Citrus sinensis 292  
orange1.1g022694m A0A067GWQ3 PAC:18096645 Citrus sinensis 293  
orange1.1g025688m A0A067GWQ8 PAC:18096647 Citrus sinensis 249  
orange1.1g027582m A0A067GJI0 PAC:18096648 Citrus sinensis 221  
orange1.1g020977m A0A067GMJ7 PAC:18096604 Citrus sinensis 319  
orange1.1g014300m A0A067GJI5 PAC:18096593 Citrus sinensis 427  
orange1.1g014464m A0A067GJJ0 PAC:18096594 Citrus sinensis 424  
orange1.1g014776m A0A067GJS8 PAC:18096595 Citrus sinensis 419  
orange1.1g014899m A0A067GJT2 PAC:18096596 Citrus sinensis 416  
orange1.1g015067m A0A067GX35 PAC:18096597 Citrus sinensis 413  
orange1.1g015509m A0A067GWR2 PAC:18096598 Citrus sinensis 405  
orange1.1g016437m A0A067GMI8 PAC:18096599 Citrus sinensis 389  
orange1.1g016603m A0A067GMJ2 PAC:18096600 Citrus sinensis 386  
orange1.1g018259m A0A067GX40 PAC:18096601 Citrus sinensis 359  
orange1.1g020943m A0A067GMJ7 PAC:18096602 Citrus sinensis 319  
orange1.1g020961m A0A067GMJ7 PAC:18096603 Citrus sinensis 319  
orange1.1g021028m A0A067GWR7 PAC:18096605 Citrus sinensis 318  

8 Publications

First Author Title Year Journal Volume Pages PubMed ID