Protein Domain : IPR018163

Type:  Domain Name:  Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain
Description:  The aminoacyl-tRNA synthetase (also known as aminoacyl-tRNA ligase) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These proteins differ widely in size and oligomeric state, and have limited sequence homology []. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric []. Class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet fold flanked by alpha-helices [], and are mostly dimeric or multimeric, containing at least three conserved regions [, , ]. However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c.This entry represents a structural domain containing a two-layer core alpha/beta structure: alpha-beta(2)-alpha-beta(2). This domain is thought to be a putative editing domain found in the N-terminal part of threonyl-tRNA synthetase (ThrRS), the C-terminal of alanyl-tRNA synthetase (AlaRS), and as the stand-alone hypothetical protein from the archaea Pyrococcus horikoshii[]; probable circular permutation of LuxS [, , ]. Short Name:  Thr/Ala-tRNA-synth_IIc_edit

0 Child Features

1 Contains

DB identifier Type Name
IPR012947 Domain Threonyl/alanyl tRNA synthetase, SAD

1 Cross References


4 Found Ins

DB identifier Type Name
IPR018165 Domain Alanyl-tRNA synthetase, class IIc, core domain
IPR002320 Family Threonine-tRNA ligase, class IIa
IPR002318 Family Alanine-tRNA ligase, class IIc
IPR022429 Family Alanine-tRNA ligase, archaea

1 GO Annotation

GO Term Gene Name Organism
GO:0000166 IPR018163

0 Parent Features

963 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
406072 D8R0K8 PAC:15413099 Selaginella moellendorffii 256  
414115 D8RRP5 PAC:15415064 Selaginella moellendorffii 322  
428079 D8T1N1 PAC:15411020 Selaginella moellendorffii 236  
447798 D8T2D3 PAC:15405452 Selaginella moellendorffii 564  
414117 D8RRP7 PAC:15415069 Selaginella moellendorffii 562  
415888 D8RXK1 PAC:15423349 Selaginella moellendorffii 264  
442211 D8RRP1 PAC:15409199 Selaginella moellendorffii 795  
116848 D8SHA2 PAC:15405711 Selaginella moellendorffii 934  
130418 D8T2D2 PAC:15421699 Selaginella moellendorffii 647  
422552 D8SIT1 PAC:15419505 Selaginella moellendorffii 262  
evm.TU.contig_28071.1 PAC:16429542 Carica papaya 273  
evm.TU.contig_29104.1 PAC:16429666 Carica papaya 77  
evm.model.supercontig_16.167 PAC:16410015 Carica papaya 218  
evm.model.supercontig_20.161 PAC:16412961 Carica papaya 515  
evm.model.supercontig_642.1 PAC:16424342 Carica papaya 390  
27543.m000154 B9SYR5 PAC:16798660 Ricinus communis 1025  
28349.m000063 B9T776 PAC:16800726 Ricinus communis 815  
29608.m000203 B9T183 PAC:16803593 Ricinus communis 658  
29726.m004035 B9RT44 PAC:16806746 Ricinus communis 107  
29883.m002043 B9S4M4 PAC:16812130 Ricinus communis 691  
Cucsa.183440.1 PAC:16967527 Cucumis sativus 414  
Cucsa.192410.1 PAC:16967976 Cucumis sativus 929  
Cucsa.192410.2 PAC:16967977 Cucumis sativus 872  
Cucsa.100510.1 A0A0A0K179 PAC:16958577 Cucumis sativus 672  
Cucsa.100510.2 PAC:16958578 Cucumis sativus 530  
Cucsa.100510.3 PAC:16958579 Cucumis sativus 484  
Cucsa.119340.1 PAC:16960972 Cucumis sativus 999  
Cucsa.271230.1 PAC:16973502 Cucumis sativus 153  
GSVIVT01024313001 D7T7I5 PAC:17832546 Vitis vinifera 267  
GSVIVT01024320001 D7T7J0 PAC:17832551 Vitis vinifera 960  

10 Publications

First Author Title Year Journal Volume Pages PubMed ID