Protein Domain : IPR001660

Type:  Domain Name:  Sterile alpha motif domain
Description:  The sterile alpha motif (SAM) domain is a putative protein interaction module present in a wide variety of proteins []involved in many biological processes. The SAM domain that spreads over around 70 residues is found in diverseeukaryotic organisms []. SAM domains have been shown to homo- and hetero-oligomerise, forming multiple self-association architectures and also binding to various non-SAMdomain-containing proteins [], nevertheless with alow affinity constant []. SAM domains also appear to possess the ability to bind RNA []. Smaug, a protein that helps to establish a morphogen gradient in Drosophila embryos byrepressing the translation of nanos (nos) mRNA, binds to the 3'untranslated region (UTR) of nosmRNA via two similar hairpin structures. The 3D crystalstructure of the Smaug RNA-binding region shows a cluster of positively charged residues on the Smaug-SAM domain, whichcould be the RNA-binding surface. This electropositive potential is unique among all previouslydetermined SAM-domain structures and is conserved among Smaug-SAM homologues. These resultssuggest that the SAM domain might have a primary role in RNA binding.Structural analyses show that the SAM domain is arranged in a small five-helix bundle with two large interfaces []. Inthe case of the SAM domain of EphB2, each of these interfaces is able to form dimers. The presence of these twodistinct intermonomers binding surface suggest that SAM could form extended polymeric structures []. Short Name:  SAM

0 Child Features

0 Contains

4 Cross Referencess


3 Found Ins

DB identifier Type Name
IPR020766 Family Receptor-like tyrosine-protein kinase kin-15/kin-16
IPR016257 Family Ephrin receptor type-A /type-B
IPR017239 Family Mitogen-activated protein (MAP) kinase kinase kinase Ste11, Cryptococcus

1 GO Annotation

GO Term Gene Name Organism
GO:0005515 IPR001660

1 Parent Features

DB identifier Type Name
IPR013761 Domain Sterile alpha motif/pointed domain

1185 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
228154 D8RP06 PAC:15405349 Selaginella moellendorffii 125  
403355 D8QTX0 PAC:15406460 Selaginella moellendorffii 416  
410658 D8RFF9 PAC:15407123 Selaginella moellendorffii 266  
270990 D8RNS3 PAC:15401922 Selaginella moellendorffii 255  
402871 D8QNB3 PAC:15407344 Selaginella moellendorffii 859  
415023 D8RUD1 PAC:15417198 Selaginella moellendorffii 679  
415475 D8RW82 PAC:15420377 Selaginella moellendorffii 769  
81847 D8R0Q2 PAC:15411397 Selaginella moellendorffii 244  
evm.model.supercontig_3.228 PAC:16416511 Carica papaya 307  
evm.TU.contig_46948.1 PAC:16432357 Carica papaya 78  
evm.model.supercontig_10.135 PAC:16404488 Carica papaya 198  
evm.model.supercontig_1218.3 PAC:16407054 Carica papaya 231  
evm.model.supercontig_14.83 PAC:16408834 Carica papaya 258  
evm.model.supercontig_222.4 PAC:16413996 Carica papaya 263  
evm.model.supercontig_4.114 PAC:16419191 Carica papaya 315  
evm.model.supercontig_5.338 PAC:16421460 Carica papaya 224  
29333.m001101 B9SDP4 PAC:16802714 Ricinus communis 253  
29736.m002112 B9S2J4 PAC:16807217 Ricinus communis 334  
29739.m003646 B9RQZ5 PAC:16807426 Ricinus communis 737  
29822.m003407 B9RUG0 PAC:16809777 Ricinus communis 318  
30090.m000241 B9SZM8 PAC:16817541 Ricinus communis 263  
30128.m009051 B9RFX9 PAC:16818633 Ricinus communis 210  
30138.m003916 B9RLI1 PAC:16819284 Ricinus communis 319  
30147.m014430 B9RA87 PAC:16820441 Ricinus communis 326  
30154.m001133 B9S0U8 PAC:16820764 Ricinus communis 261  
27446.m000497 B9SWU8 PAC:16798357 Ricinus communis 193  
30204.m001736 B9S502 PAC:16823854 Ricinus communis 207  
Cucsa.157020.1 A0A0A0LRM8 PAC:16964932 Cucumis sativus 304  
Cucsa.157020.2 A0A0A0LRM8 PAC:16964933 Cucumis sativus 304  
Cucsa.158850.1 PAC:16965178 Cucumis sativus 333  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID