Protein Domain : IPR020059

Type:  Domain Name:  Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain
Description:  The aminoacyl-tRNA synthetase (also known as aminoacyl-tRNA ligase) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These proteins differ widely in size and oligomeric state, and have limited sequence homology []. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric []. Class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet fold flanked by alpha-helices [], and are mostly dimeric or multimeric, containing at least three conserved regions [, , ]. However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c.Glutamate-tRNA ligase (also known as glutamyl-tRNA synthetase)() is a class Ic ligase and shows several similarities with glutamate-tRNA ligase concerning structure and catalytic properties. It is an alpha2 dimer. To date one crystal structure of a glutamate-tRNA ligase (Thermus thermophilus) has been solved. The molecule has the form of a bent cylinder and consists of four domains. The N-terminal half (domains 1 and 2) contains the 'Rossman fold' typical for class I ligases and resembles the corresponding part of Escherichia coliGlnRS, whereas the C-terminal half exhibits a GluRS-specific structure []. Short Name:  Glu/Gln-tRNA-synth_Ib_codon-bd

0 Child Features

1 Contains

DB identifier Type Name
IPR020056 Domain Ribosomal protein L25/Gln-tRNA synthetase, beta-barrel domain

1 Cross References


3 Found Ins

DB identifier Type Name
IPR004514 Family Glutamine-tRNA synthetase
IPR000924 Family Glutamyl/glutaminyl-tRNA synthetase
IPR004526 Family Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic

5 GO Annotations

GO Term Gene Name Organism
GO:0000166 IPR020059
GO:0004812 IPR020059
GO:0005524 IPR020059
GO:0006418 IPR020059
GO:0005737 IPR020059

1 Parent Features

DB identifier Type Name
IPR011035 Domain Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain

498 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
168502 D8R589 PAC:15422789 Selaginella moellendorffii 767  
404079 D8QU78 PAC:15407088 Selaginella moellendorffii 760  
78641 D8QV01 PAC:15422958 Selaginella moellendorffii 763  
121308 D8SNX9 PAC:15416746 Selaginella moellendorffii 731  
evm.model.supercontig_248.3 PAC:16414659 Carica papaya 729  
evm.model.supercontig_798.2 PAC:16426373 Carica papaya 795  
30066.m000715 B9SLX3 PAC:16816481 Ricinus communis 793  
30128.m008996 B9RFS6 PAC:16818580 Ricinus communis 728  
Cucsa.051070.1 A0A0A0LYW4 PAC:16954173 Cucumis sativus 729  
Cucsa.109570.1 A0A0A0LIR0 PAC:16959890 Cucumis sativus 794  
Cucsa.234080.1 A0A0A0LMF7 PAC:16970337 Cucumis sativus 793  
GSVIVT01031352001 PAC:17837566 Vitis vinifera 276  
GSVIVT01018308001 D7SM09 PAC:17828299 Vitis vinifera 790  
GSVIVT01011871001 D7T929 PAC:17823632 Vitis vinifera 791  
orange1.1g003751m A0A067GBB7 PAC:18139049 Citrus sinensis 798  
orange1.1g003764m A0A067GBI4 PAC:18139050 Citrus sinensis 797  
orange1.1g004119m A0A067GE73 PAC:18139051 Citrus sinensis 773  
orange1.1g004546m A0A067GNR0 PAC:18139052 Citrus sinensis 745  
orange1.1g007060m A0A067GBC2 PAC:18139054 Citrus sinensis 619  
orange1.1g012516m A0A067GBI9 PAC:18139055 Citrus sinensis 462  
orange1.1g043341m A0A067DV09 PAC:18107196 Citrus sinensis 758  
AT5G26710.1 O82462 PAC:19670447 Arabidopsis thaliana 719  
AT1G25350.2 F4ICG2 PAC:19655198 Arabidopsis thaliana 800  
AT5G19720.1 F4K2L4 PAC:19665255 Arabidopsis thaliana 170  
AT1G25350.1 Q8W4F3 PAC:19655199 Arabidopsis thaliana 795  
Thhalv10006840m V4KSE7 PAC:20187784 Eutrema salsugineum 795  
Thhalv10003717m V4KQB9 PAC:20198437 Eutrema salsugineum 724  
Ciclev10014367m V4W6G7 PAC:20818597 Citrus clementina 762  
Ciclev10014320m V4UHD9 PAC:20818595 Citrus clementina 797  
Ciclev10014321m V4U700 PAC:20818596 Citrus clementina 796  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID