Protein Domain : IPR019956

Type:  Family Name:  Ubiquitin
Description:  Ubiquitinylation is an ATP-dependent process that involves the action of at least three enzymes: a ubiquitin-activating enzyme (E1, ), a ubiquitin-conjugating enzyme (E2, ), and a ubiquitin ligase (E3, , ), which work sequentially in a cascade. There are many different E3 ligases, which are responsible for the type of ubiquitin chain formed, the specificity of the target protein, and the regulation of the ubiquitinylation process []. Ubiquitinylation is an important regulatory tool that controls the concentration of key signalling proteins, such as those involved in cell cycle control, as well as removing misfolded, damaged or mutant proteins that could be harmful to the cell. Several ubiquitin-like molecules have been discovered, such as Ufm1 (), SUMO1 (), NEDD8, Rad23 (), Elongin B and Parkin (), the latter being involved in Parkinson's disease [].Ubiquitin is a protein of 76 amino acid residues, found in all eukaryotic cells and whose sequence is extremely well conserved from protozoan to vertebrates. Ubiquitin acts through its post-translational attachment (ubiquitinylation) to other proteins, where these modifications alter the function, location or trafficking of the protein, or targets it for destruction by the 26S proteasome []. The terminal glycine in the C-terminal 4-residue tail of ubiquitin can form an isopeptide bond with a lysine residue in the target protein, or with a lysine in another ubiquitin molecule to form a ubiquitin chain that attaches itself to a target protein. Ubiquitin has seven lysine residues, any one of which can be used to link ubiquitin molecules together, resulting in different structures that alter the target protein in different ways. It appears that Lys(11)-, Lys(29) and Lys(48)-linked poly-ubiquitin chains target the protein to the proteasome for degradation, while mono-ubiquitinylated and Lys(6)- or Lys(63)-linked poly-ubiquitin chains signal reversible modifications in protein activity, location or trafficking []. For example, Lys(63)-linked poly-ubiquitinylation is known to be involved in DNA damage tolerance, inflammatory response, protein trafficking and signal transduction through kinase activation []. In addition, the length of the ubiquitin chain alters the fate of the target protein. Regulatory proteins such as transcription factors and histones are frequent targets of ubquitinylation []. Short Name:  Ubiquitin

0 Child Features

1 Contains

DB identifier Type Name
IPR019954 Conserved_site Ubiquitin conserved site

1 Cross References

Identifier
PR00348

0 Found In

0 GO Annotation

0 Parent Features

1185 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
163447 D8TBD2 PAC:15407474 Selaginella moellendorffii 382  
171198 D8RG44 PAC:15406719 Selaginella moellendorffii 536  
270468 D8R1K6 PAC:15420357 Selaginella moellendorffii 535  
271419 D8S9W3 PAC:15423042 Selaginella moellendorffii 306  
93613 D8RGT0 PAC:15422732 Selaginella moellendorffii 108  
101548 D8RT32 PAC:15403856 Selaginella moellendorffii 78  
138728 D8TBP0 PAC:15402793 Selaginella moellendorffii 229  
173723 D8RS28 PAC:15417062 Selaginella moellendorffii 457  
187148 D8TBP0 PAC:15409040 Selaginella moellendorffii 229  
227280 D8QSE0 PAC:15403272 Selaginella moellendorffii 687  
228943 D8RZG9 PAC:15411578 Selaginella moellendorffii 381  
271198 D8RZG9 PAC:15420990 Selaginella moellendorffii 381  
19615 D8S8X4 PAC:15404994 Selaginella moellendorffii 78  
162003 D8S9W3 PAC:15401495 Selaginella moellendorffii 306  
439993 D8R8R3 PAC:15405638 Selaginella moellendorffii 866  
50844 D8SEY7 PAC:15409152 Selaginella moellendorffii 800  
evm.model.supercontig_3.136 PAC:16416409 Carica papaya 128  
evm.model.supercontig_3.81 PAC:16416868 Carica papaya 367  
evm.TU.contig_27582.1 PAC:16429516 Carica papaya 476  
evm.model.supercontig_104.105 PAC:16405005 Carica papaya 128  
evm.model.supercontig_12.91 PAC:16406935 Carica papaya 409  
evm.model.supercontig_198.11 PAC:16412373 Carica papaya 518  
evm.model.supercontig_26.230 PAC:16415173 Carica papaya 192  
evm.model.supercontig_34.2 PAC:16417937 Carica papaya 93  
evm.model.supercontig_3792.1 PAC:16418841 Carica papaya 634  
evm.model.supercontig_543.3 A0A0N9Y016 PAC:16422461 Carica papaya 156  
evm.model.supercontig_69.73 PAC:16424946 Carica papaya 156  
evm.model.supercontig_97.60 PAC:16429098 Carica papaya 447  
evm.model.supercontig_97.61 PAC:16429099 Carica papaya 281  
28617.m000205 B9T453 PAC:16801268 Ricinus communis 157  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            15454246
            14998368
            15556404
            12646216
            15564047
            15525528