Protein Domain : IPR019734

Type:  Repeat Name:  Tetratricopeptide repeat
Description:  The tetratrico peptide repeat region (TPR) is a structural motif present in a wide range of proteins [, , ]. It mediates protein-protein interactions and the assembly of multiprotein complexes []. The TPR motifconsists of 3-16 tandem-repeats of 34 amino acids residues, although individual TPR motifs canbe dispersed in the protein sequence. Sequence alignment of the TPR domains reveals aconsensus sequence defined by a pattern of small and large amino acids. TPR motifs have beenidentified in various different organisms, ranging from bacteria to humans. Proteins containingTPRs are involved in a variety of biological processes, such as cell cycle regulation,transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis andprotein folding.The X-ray structure of a domain containing three TPRs from protein phosphatase 5 revealed thatTPR adopts a helix-turn-helix arrangement, with adjacent TPR motifs packing in a parallelfashion, resulting in a spiral of repeating anti-parallel alpha-helices []. The two helices are denotedhelix A and helix B. The packing angle between helix A and helix B is ~24 degrees within asingle TPR and generates a right-handed superhelical shape. Helix A interacts with helix B andwith helix A' of the next TPR. Two protein surfaces are generated: the inner concave surface iscontributed to mainly by residue on helices A, and the other surface presents residues from bothhelices A and B. Short Name:  TPR_repeat

0 Child Features

0 Contains

5 Cross Referencess

Identifier
PF13174
PF13176
PF13181
PS50005
SM00028

5 Found Ins

DB identifier Type Name
IPR021183 Family N-terminal acetyltransferase A, auxiliary subunit
IPR015374 Family Chs5p-Arf1p binding
IPR019544 Domain Tetratricopeptide, SHNi-TPR domain
IPR001237 Family 43kDa postsynaptic protein
IPR019568 Domain Rapsyn, myristoylation/linker region, N-terminal

1 GO Annotation

GO Term Gene Name Organism
GO:0005515 IPR019734

0 Parent Features

20417 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
107379 D8S3B5 PAC:15420062 Selaginella moellendorffii 87  
115934 D8SFV6 PAC:15403473 Selaginella moellendorffii 1076  
123922 D8SSG2 PAC:15404802 Selaginella moellendorffii 668  
149863 D8RTU4 PAC:15413967 Selaginella moellendorffii 1041  
160429 D8T2I3 PAC:15421037 Selaginella moellendorffii 236  
183465 D8SX41 PAC:15421947 Selaginella moellendorffii 809  
231593 D8RGU7 PAC:15417663 Selaginella moellendorffii 289  
272183 D8T687 PAC:15401589 Selaginella moellendorffii 538  
404439 D8QVB9 PAC:15410206 Selaginella moellendorffii 689  
406722 D8R189 PAC:15418290 Selaginella moellendorffii 355  
410232 D8RE28 PAC:15404033 Selaginella moellendorffii 354  
411103 D8RGL0 PAC:15406167 Selaginella moellendorffii 860  
411739 D8RIW4 PAC:15410942 Selaginella moellendorffii 371  
412702 D8RL78 PAC:15413814 Selaginella moellendorffii 140  
416844 D8S0K8 PAC:15403837 Selaginella moellendorffii 309  
417136 D8S1H3 PAC:15401489 Selaginella moellendorffii 588  
419030 D8S7L0 PAC:15406530 Selaginella moellendorffii 733  
42040 D8SVN0 PAC:15401643 Selaginella moellendorffii 593  
420781 D8SD34 PAC:15415338 Selaginella moellendorffii 380  
421229 D8SEE9 PAC:15414309 Selaginella moellendorffii 387  
428314 D8T2F3 PAC:15413182 Selaginella moellendorffii 243  
431495 D8TCU6 PAC:15422993 Selaginella moellendorffii 442  
438270 D8QVI4 PAC:15419699 Selaginella moellendorffii 1912  
439259 D8R357 PAC:15422503 Selaginella moellendorffii 581  
439621 D8R6I2 PAC:15403132 Selaginella moellendorffii 326  
443450 D8S1K0 PAC:15413838 Selaginella moellendorffii 567  
444100 D8S6F9 PAC:15414330 Selaginella moellendorffii 1047  
61985 D8RHP3 PAC:15420136 Selaginella moellendorffii 408  
74711 D8QPQ0 PAC:15412089 Selaginella moellendorffii 281  
80159 PAC:15403009 Selaginella moellendorffii 241  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9482716
            7667876
            1882418
            14659697