Protein Domain : IPR001680

Type:  Repeat Name:  WD40 repeat
Description:  WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs, often terminating in a Trp-Asp (W-D) dipeptide. WD40 repeats usually assume a 7-8 bladed beta-propeller fold, but proteins have been found with 4 to 16 repeated units, which also form a circularised beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. Repeated WD40 motifs act as a site for protein-protein interaction, and proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins. The specificity of the proteins is determined by the sequences outside the repeats themselves. Examples of such complexes are G proteins (beta subunit is a beta-propeller), TAFII transcription factor, and E3 ubiquitin ligase [, ]. In Arabidopsis spp., several WD40-containing proteins act as key regulators of plant-specific developmental events. Short Name:  WD40_repeat

0 Child Features

1 Contains

DB identifier Type Name
IPR019775 Conserved_site WD40 repeat, conserved site

3 Cross Referencess


21 Found Ins

DB identifier Type Name
IPR017986 Domain WD40-repeat-containing domain
IPR015943 Domain WD40/YVTN repeat-like-containing domain
IPR001632 Domain G-protein, beta subunit
IPR016346 Family Guanine nucleotide-binding protein, beta subunit
IPR004083 Family Regulatory associated protein of TOR
IPR016453 Family Coatomer beta' subunit (COPB2)
IPR000009 Family Protein phosphatase 2A regulatory subunit PR55
IPR017383 Family Actin-related protein 2/3 complex subunit 1
IPR016902 Family Vacuolar protein sorting-associated protein 41
IPR013905 Domain Lethal giant larvae (Lgl)-like, C-terminal domain
IPR017399 Family WD repeat protein DCAF11/LEC14B
IPR016391 Family Coatomer alpha subunit
IPR017422 Family WD repeat protein 55
IPR009146 Family Groucho/transducin-like enhancer
IPR015505 Family Coronin
IPR017149 Family Glutathione degradosome, DUG2
IPR017252 Family Dynein regulator LIS1
IPR017251 Family Apoptotic protease-activating factor 1
IPR000664 Family Lethal(2) giant larvae protein
IPR017233 Family WD repeat protein 35
IPR013577 Domain Lethal giant larvae homologue 2

1 GO Annotation

GO Term Gene Name Organism
GO:0005515 IPR001680

0 Parent Features

35494 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
106210 D8S1J6 PAC:15416247 Selaginella moellendorffii 308  
109958 D8S6N9 PAC:15408016 Selaginella moellendorffii 317  
110677 D8S7B1 PAC:15409058 Selaginella moellendorffii 444  
121554 D8SNS5 PAC:15418401 Selaginella moellendorffii 442  
134213 D8T8C5 PAC:15409638 Selaginella moellendorffii 406  
139237 D8QPF0 PAC:15401990 Selaginella moellendorffii 396  
139346 D8QPW0 PAC:15402692 Selaginella moellendorffii 737  
157928 D8SSK2 PAC:15415923 Selaginella moellendorffii 320  
173029 D8RNT8 PAC:15411729 Selaginella moellendorffii 346  
176503 D8S386 PAC:15401916 Selaginella moellendorffii 372  
182327 D8SSL1 PAC:15418267 Selaginella moellendorffii 1609  
183457 D8SX24 PAC:15421927 Selaginella moellendorffii 351  
230840 D8R6E0 PAC:15416924 Selaginella moellendorffii 490  
230900 D8R525 PAC:15417580 Selaginella moellendorffii 1340  
233294 D8S7F5 PAC:15421115 Selaginella moellendorffii 408  
233900 D8SFJ6 PAC:15403891 Selaginella moellendorffii 309  
266832 D8R1U5 PAC:15411407 Selaginella moellendorffii 392  
269383 D8SYB1 PAC:15416400 Selaginella moellendorffii 323  
269750 D8T680 PAC:15419395 Selaginella moellendorffii 307  
3288 D8RE96 PAC:15411506 Selaginella moellendorffii 194  
402415 D8QQJ8 PAC:15404159 Selaginella moellendorffii 330  
404454 D8QVD7 PAC:15410252 Selaginella moellendorffii 617  
410492 D8REX6 PAC:15405756 Selaginella moellendorffii 835  
419453 D8S904 PAC:15409679 Selaginella moellendorffii 552  
421824 D8SGH1 PAC:15418832 Selaginella moellendorffii 469  
426332 D8SW20 PAC:15407197 Selaginella moellendorffii 602  
437796 D8QTR7 PAC:15420626 Selaginella moellendorffii 1303  
442028 D8RQR3 PAC:15407580 Selaginella moellendorffii 806  
442453 D8RTJ1 PAC:15410870 Selaginella moellendorffii 466  
60006 D8R527 PAC:15410182 Selaginella moellendorffii 2715  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID