Protein Domain : IPR014001

Type:  Domain Name:  Helicase superfamily 1/2, ATP-binding domain
Description:  Helicases have been classified in 5 superfamilies (SF1-SF5). All of theproteins bind ATP and, consequently, all of them carry the classical Walker A(phosphate-binding loop or P-loop) and Walker B(Mg2+-binding aspartic acid) motifs. For the two largest groups, commonlyreferred to as SF1 and SF2, a total of seven characteristic motifs has beenidentified []. These two superfamilies encompass a large number of DNA and RNA helicases from archaea, eubacteria, eukaryotes and viruses that seem to be active as monomers or dimers. RNA and DNA helicases are considered to be enzymes that catalyse the separation of double-stranded nucleic acids in an energy-dependent manner [].The various structures ofSF1 and SF2 helicases present a common core with two alpha-beta RecA-like domains [, ]. Thestructural homology with the RecA recombination protein covers the fivecontiguous parallel beta strands and the tandem alpha helices. ATP binds tothe amino proximal alpha-beta domain, where the Walker A (motif I) and WalkerB (motif II) are found. The N-terminal domain also contains motif III (S-A-T)which was proposed to participate in linking ATPase and helicase activities.The carboxy-terminal alpha-beta domain is structurally very similar to theproximal one even though it is bereft of an ATP-binding site, suggesting thatit may have originally arisen through gene duplication of the first one.This entry represents the DNA-binding domain of classical SF1 and SF2 helicases. Short Name:  Helicase_ATP-bd

3 Child Features

DB identifier Type Name
IPR006935 Domain Helicase/UvrB, N-terminal
IPR011545 Domain DEAD/DEAH box helicase domain
IPR011492 Domain DEAD box, Flavivirus

4 Contains

DB identifier Type Name
IPR014013 Domain Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type
IPR010614 Domain DEAD2
IPR000629 Conserved_site ATP-dependent RNA helicase DEAD-box, conserved site
IPR002464 Conserved_site DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site

2 Cross Referencess


14 Found Ins

DB identifier Type Name
IPR000330 Domain SNF2-related, N-terminal domain
IPR004589 Family DNA helicase, ATP-dependent, RecQ type
IPR004483 Family Helicase SMUBP-2/Hcs1-like
IPR004473 Family Restriction endonuclease, type I, HsdR
IPR004807 Family UvrABC system, subunit B
IPR010225 Family RNA helicase, ATP-dependent DEAH box, HrpB-type
IPR006293 Family DNA helicase, ATP-dependent, RecQ type, bacterial
IPR022307 Family DEAD/DEAH-box helicase, putative, actinobacteria
IPR010222 Family RNA helicase HrpA
IPR017575 Family CRISPR-associated helicase, CYANO-type
IPR017548 Family CRISPR-associated DEAD/DEAH-boxhelicase Csf4
IPR003450 Domain Replication origin-binding protein
IPR006474 Domain Helicase Cas3, CRISPR-associated, core
IPR006310 Family DnaQ exonuclease/DinG helicase, predicted

0 GO Annotation

0 Parent Features

25757 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
102612 D8RVF8 PAC:15407465 Selaginella moellendorffii 492  
102849 D8RVC9 PAC:15409196 Selaginella moellendorffii 1017  
10677 D8RBM0 PAC:15423455 Selaginella moellendorffii 614  
111217 D8S921 PAC:15408757 Selaginella moellendorffii 500  
122946 D8SRE5 PAC:15402018 Selaginella moellendorffii 167  
123861 D8SSL0 PAC:15404123 Selaginella moellendorffii 593  
147068 D8RGS1 PAC:15401889 Selaginella moellendorffii 713  
149865 D8RTU5 PAC:15413971 Selaginella moellendorffii 523  
164382 D8QNK4 PAC:15409852 Selaginella moellendorffii 401  
173103 D8RP98 PAC:15412444 Selaginella moellendorffii 962  
186944 D8TAU2 PAC:15412286 Selaginella moellendorffii 1825  
230853 D8R6I4 PAC:15416941 Selaginella moellendorffii 711  
232454 D8RVC4 PAC:15419726 Selaginella moellendorffii 408  
235696 PAC:15407665 Selaginella moellendorffii 721  
30996 D8T3N2 PAC:15417959 Selaginella moellendorffii 640  
402571 D8QR38 PAC:15405093 Selaginella moellendorffii 935  
413731 D8RQ16 PAC:15416714 Selaginella moellendorffii 707  
438275 D8QVL3 PAC:15419705 Selaginella moellendorffii 2074  
444050 D8S6W1 PAC:15413673 Selaginella moellendorffii 1426  
441970 D8RPA1 PAC:15411809 Selaginella moellendorffii 872  
50132 D8S5Z7 PAC:15403700 Selaginella moellendorffii 908  
74321 D8QNJ9 PAC:15409014 Selaginella moellendorffii 1291  
75384 D8QQR1 PAC:15412124 Selaginella moellendorffii 575  
76516 D8QS10 PAC:15416385 Selaginella moellendorffii 616  
77276 D8QSX3 PAC:15417173 Selaginella moellendorffii 704  
80139 D8QXG2 PAC:15402970 Selaginella moellendorffii 959  
81713 D8QYP9 PAC:15410557 Selaginella moellendorffii 633  
82212 D8R071 PAC:15409607 Selaginella moellendorffii 1040  
86079 D8R591 PAC:15419919 Selaginella moellendorffii 464  
86110 D8R6I9 PAC:15420555 Selaginella moellendorffii 1730  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID