Protein Domain : IPR001611

Type:  Repeat Name:  Leucine-rich repeat
Description:  Leucine-rich repeats (LRR) consist of 2-45 motifs of 20-30 amino acids in length that generally folds into an arc or horseshoe shape []. LRRs occur in proteins ranging from viruses to eukaryotes, and appear to provide a structural framework for the formation of protein-protein interactions [, ].Proteins containing LRRs include tyrosine kinase receptors, cell-adhesion molecules, virulence factors, and extracellular matrix-binding glycoproteins, and are involved in a variety of biological processes, including signal transduction, cell adhesion, DNA repair, recombination, transcription, RNA processing, disease resistance, apoptosis, and the immune response [].Sequence analyses of LRR proteins suggested the existence of several different subfamilies of LRRs. The significance of this classification is that repeats from different subfamilies never occur simultaneously and have most probably evolved independently. It is, however, now clear that all major classes of LRR have curved horseshoe structures with a parallel beta sheet on the concave side and mostly helical elements on the convex side. At least six families of LRR proteins, characterised by different lengths and consensus sequences of the repeats, have been identified. Eleven-residue segments of the LRRs (LxxLxLxxN/CxL), corresponding to the beta-strand and adjacent loop regions, are conserved in LRR proteins, whereas the remaining parts of the repeats (herein termed variable) may be very different. Despite the differences, each of the variable parts contains two half-turns at both ends and a "linear" segment (as the chain follows a linear path overall), usually formed by a helix, in the middle. The concave face and the adjacent loops are the most common protein interaction surfaces on LRR proteins. 3D structure of some LRR proteins-ligand complexes show that the concave surface of LRR domain is ideal for interaction with alpha-helix, thus supporting earlier conclusions that the elongated and curved LRR structure provides an outstanding framework for achieving diverse protein-protein interactions []. Molecular modeling suggests that the conserved pattern LxxLxL, which is shorter than the previously proposed LxxLxLxxN/CxL is sufficient to impart the characteristic horseshoe curvature to proteins with 20- to 30-residue repeats []. Short Name:  Leu-rich_rpt

0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF00560
PF13855
PS51450

5 Found Ins

DB identifier Type Name
IPR017241 Family Toll-like receptor
IPR002272 Family Follicle stimulating hormone receptor
IPR016337 Family Monocyte differentiation antigen CD14
IPR016352 Family Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan
IPR008112 Family Relaxin receptor

1 GO Annotation

GO Term Gene Name Organism
GO:0005515 IPR001611

0 Parent Features

60622 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
109362 D8S5S6 PAC:15403455 Selaginella moellendorffii 116  
100869 D8RT54 PAC:15403317 Selaginella moellendorffii 345  
100988 D8RT55 PAC:15404100 Selaginella moellendorffii 211  
110183 D8S7G4 PAC:15405215 Selaginella moellendorffii 437  
114118 D8SCE4 PAC:15416826 Selaginella moellendorffii 507  
122408 D8SQ96 PAC:15420456 Selaginella moellendorffii 724  
124565 D8STG2 PAC:15404758 Selaginella moellendorffii 144  
126823 D8SWU4 PAC:15412940 Selaginella moellendorffii 430  
131809 D8T4S1 PAC:15405368 Selaginella moellendorffii 193  
164315 D8QND5 PAC:15409665 Selaginella moellendorffii 981  
169795 D8RB18 PAC:15405165 Selaginella moellendorffii 947  
17181 D8RPF6 PAC:15417870 Selaginella moellendorffii 165  
173095 D8RP74 PAC:15411886 Selaginella moellendorffii 668  
175461 D8RYQ5 PAC:15420671 Selaginella moellendorffii 894  
178079 D8S9Q1 PAC:15403990 Selaginella moellendorffii 704  
17907 D8SU67 PAC:15401481 Selaginella moellendorffii 119  
183219 D8SVZ9 PAC:15420396 Selaginella moellendorffii 317  
18672 D8T3A0 PAC:15402273 Selaginella moellendorffii 113  
233681 D8SD33 PAC:15401912 Selaginella moellendorffii 387  
234577 D8SMM4 PAC:15403911 Selaginella moellendorffii 938  
25710 D8RR80 PAC:15401284 Selaginella moellendorffii 113  
268021 D8S0E1 PAC:15411149 Selaginella moellendorffii 945  
30384 D8S9J0 PAC:15413428 Selaginella moellendorffii 1051  
30446 D8RRF3 PAC:15414128 Selaginella moellendorffii 983  
31754 D8QXW9 PAC:15419266 Selaginella moellendorffii 536  
37978 D8STG3 PAC:15416113 Selaginella moellendorffii 97  
402612 D8QR82 PAC:15405749 Selaginella moellendorffii 761  
403970 D8QT56 PAC:15411218 Selaginella moellendorffii 447  
404255 D8QUS1 PAC:15408610 Selaginella moellendorffii 370  
404787 D8QXC6 PAC:15412611 Selaginella moellendorffii 1068  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1657640
            2176636
            11751054
            11967365
            14747988