Protein Domain : IPR000719

Type:  Domain Name:  Protein kinase domain
Description:  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by proteinkinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Eukaryotic protein kinases [, , , , ]are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue, which has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme []. This entry represents the protein kinase domain containing the catalytic function of protein kinases []. This domain is found in serine/threonine-protein kinases, tyrosine-protein kinases and dual specificity protein kinases. Short Name:  Prot_kinase_dom

3 Child Features

DB identifier Type Name
IPR001245 Domain Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Domain Serine/threonine/dual specificity protein kinase, catalytic domain
IPR027916 Domain Protein kinase-like domain, Apicomplexa

6 Contains

DB identifier Type Name
IPR017441 Binding_site Protein kinase, ATP binding site
IPR001824 Conserved_site Tyrosine-protein kinase, receptor class III, conserved site
IPR008266 Active_site Tyrosine-protein kinase, active site
IPR002011 Conserved_site Tyrosine-protein kinase, receptor class II, conserved site
IPR008271 Active_site Serine/threonine-protein kinase, active site
IPR003527 Conserved_site Mitogen-activated protein (MAP) kinase, conserved site

2 Cross Referencess

Identifier
PF00069
PS50011

55 Found Ins

DB identifier Type Name
IPR020636 Family Calcium/calmodulin-dependent/calcium-dependent protein kinase
IPR017348 Family Serine/threonine-protein kinase pim-1/2/3
IPR016243 Family Tyrosine-protein kinase, CSF-1/PDGF receptor family
IPR009136 Family Vascular endothelial growth factor receptor 2 (VEGFR2)
IPR020691 Family Ephrin type-A receptor 8
IPR016246 Family Tyrosine-protein kinase, insulin-like receptor
IPR016251 Family Tyrosine-protein kinase, non-receptor Jak/Tyk2
IPR020775 Family Tyrosine-protein kinase, non-receptor Jak3
IPR020693 Family Tyrosine-protein kinase, non-receptor Jak2
IPR020776 Family Tyrosine-protein kinase, non-receptor Jak1
IPR020766 Family Receptor-like tyrosine-protein kinase kin-15/kin-16
IPR020777 Family Tyrosine-protein kinase, neurotrophic receptor
IPR020446 Family Tyrosine-protein kinase, neurotrophic receptor, type 3
IPR020455 Family Tyrosine-protein kinase, neurotrophic receptor, type 2
IPR020461 Family Tyrosine-protein kinase, neurotrophic receptor, type 1
IPR020679 Family Serine/threonine-protein kinase Tda1
IPR020675 Family Myosin light chain kinase-related
IPR015725 Family Telokin/Myosin light chain kinase
IPR015726 Family Serine/threonine protein kinase, striated muscle-specific
IPR020676 Family Death-associated protein kinase 1
IPR016257 Family Ephrin receptor type-A /type-B
IPR020684 Family Rho-associated protein kinase 1/2
IPR020682 Family Obscurin-myosin light chain kinase
IPR017322 Family Receptor-interacting serine/threonine-protein kinase 2
IPR009220 Family Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
IPR012234 Family Tyrosine-protein kinase, non-receptor SYK/ZAP-70
IPR015782 Family Dual specificity testis-specific protein kinase 1
IPR015785 Family Mitogen-activated protein (MAP) kinase kinase kinase 10
IPR021160 Family Mitogen-activated protein (MAP) kinase kinase kinase kinase
IPR016231 Family Mitogen-activated protein (MAP) kinase kinase kinase, MLK1/MLK2/MLK4

3 GO Annotations

GO Term Gene Name Organism
GO:0004672 IPR000719
GO:0005524 IPR000719
GO:0006468 IPR000719

1 Parent Features

DB identifier Type Name
IPR011009 Domain Protein kinase-like domain

179668 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
109699 D8S6U8 PAC:15405864 Selaginella moellendorffii 627  
134331 D8T8A1 PAC:15410494 Selaginella moellendorffii 395  
134757 D8T936 PAC:15413620 Selaginella moellendorffii 122  
139837 D8QMU8 PAC:15406526 Selaginella moellendorffii 246  
151233 D8RZA1 PAC:15415404 Selaginella moellendorffii 450  
27379 D8QXH0 PAC:15404180 Selaginella moellendorffii 185  
108195 D8S4E3 PAC:15421379 Selaginella moellendorffii 325  
109282 D8S5L8 PAC:15402759 Selaginella moellendorffii 624  
100958 D8RT90 PAC:15404039 Selaginella moellendorffii 400  
101192 PAC:15423268 Selaginella moellendorffii 333  
101524 D8RSZ6 PAC:15403794 Selaginella moellendorffii 221  
102667 D8RV74 PAC:15407595 Selaginella moellendorffii 455  
103488 D8RWR1 PAC:15409147 Selaginella moellendorffii 561  
103506 D8RWQ7 PAC:15409702 Selaginella moellendorffii 455  
109677 D8S6U3 PAC:15405823 Selaginella moellendorffii 353  
10499 D8SYB4 PAC:15421970 Selaginella moellendorffii 675  
105160 D8RZA3 PAC:15412674 Selaginella moellendorffii 551  
105905 D8S0G7 PAC:15418654 Selaginella moellendorffii 395  
106238 D8S1F1 PAC:15416292 Selaginella moellendorffii 85  
106578 D8S1H5 PAC:15418686 Selaginella moellendorffii 73  
110120 D8S6E1 PAC:15405055 Selaginella moellendorffii 292  
110333 D8S7C8 PAC:15406643 Selaginella moellendorffii 256  
110515 D8S7B9 PAC:15408061 Selaginella moellendorffii 256  
112714 D8SA18 PAC:15415612 Selaginella moellendorffii 169  
111790 D8S984 PAC:15412827 Selaginella moellendorffii 456  
11420 D8RT06 PAC:15402447 Selaginella moellendorffii 411  
117448 D8SID3 PAC:15405568 Selaginella moellendorffii 301  
118910 D8SKB3 PAC:15412328 Selaginella moellendorffii 285  
122114 D8SQ17 PAC:15418159 Selaginella moellendorffii 67  
122408 D8SQ96 PAC:15420456 Selaginella moellendorffii 724  

10 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3291115
            12368087
            12471243
            15078142
            15320712
            7768349
            1835513
            1956325
            1862342
            12734000