Protein Domain : IPR012582

Type:  Domain Name:  NUC194
Description:  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].This is domain B in the catalytic subunit of DNA-dependent protein kinases. Short Name:  NUC194

0 Child Features

0 Contains

1 Cross References


1 Found In

DB identifier Type Name
IPR016024 Domain Armadillo-type fold

5 GO Annotations

GO Term Gene Name Organism
GO:0003677 IPR012582
GO:0004677 IPR012582
GO:0005524 IPR012582
GO:0006303 IPR012582
GO:0005634 IPR012582

0 Parent Features

13 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
63567 I0YXU1 PAC:27392389 Coccomyxa subellipsoidea C-169 2536  
17614 PAC:27417165 Ostreococcus lucimarinus 3912  
Cre09.g397327.t1.1 PAC:30781509 Chlamydomonas reinhardtii 6856  
Sphfalx0167s0024.1.p PAC:32617584 Sphagnum fallax 4146  
Vocar.0009s0222.1.p PAC:32893448 Volvox carteri 4384  
Pp3c9_15240V3.1.p PAC:32914053 Physcomitrella patens 4098  
Pp3c9_15240V3.4.p PAC:32914055 Physcomitrella patens 4098  
Pp3c9_15240V3.3.p PAC:32914056 Physcomitrella patens 4097  
Pp3c9_15240V3.2.p PAC:32914054 Physcomitrella patens 4098  
Mapoly0069s0061.1.p PAC:33018801 Marchantia polymorpha 4152  
Mapoly0069s0061.2.p PAC:33018802 Marchantia polymorpha 4152  
Cz16g08300.t1 PAC:38239545 Chromochloris zofingiensis 3599  
Bobra.39_1s0001.1.p PAC:40704333 Botryococcus braunii Showa 2932  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID