Protein Domain : IPR004517

Type:  Family Name:  ATP phosphoribosyltransferase regulatory subunit
Description:  Protein in this entry are mostly annotated as the ATP phosphoribosyltransferase regulatory subunit (HisZ). However, this entry also includes some histidine-tRNA ligases (HisS or HisRS), which is the paralogue of HisZ. Despite the significant sequential and structural similarity, HisRS and HisZ have different functions []. HisRS is a class IIa aminoacyl-tRNA synthetase (ligase), while HisZ is a regulatory subunit of the hetero-octameric ATP phosphoribosyl transferase that regulate reactions initiating histidine biosynthesis [, ]. From the phylogenetic analysis, HisZ proteins form a monophyletic group that attaches outside the predominant bacterial HisRS clade []. HisZ are represented in a highly divergent set of bacteria (including an aquificale, cyanobacteria, firmicutes, and proteobacteria), but are missing from other bacteria, including mycrobacteria and certain proteobacteria []. It has been suggested that the absences of HisZ from bacteria are due to its loss during evolution []. Short Name:  HisZ

0 Child Features

2 Contains

DB identifier Type Name
IPR006195 Domain Aminoacyl-tRNA synthetase, class II
IPR002314 Domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)

2 Cross Referencess


0 Found In

2 GO Annotations

GO Term Gene Name Organism
GO:0000105 IPR004517
GO:0005737 IPR004517

1 Parent Features

DB identifier Type Name
IPR004516 Family Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID