Protein Domain : IPR016239

Type:  Family Name:  Ribosomal protein S6 kinase II
Description:  This entry represents ribosomal protein S6 kinase II []. This enzyme acts as a serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). It plays an essential role in the control of RELA transcriptional activity in response to TNF. It directly represses transcription via phosphorylation of Ser-1 of histone H2A. It phosphorylates Ser-10 of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. It mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14). It requires magnesium ions as a cofactor. Short Name:  Ribosomal_S6_kinase_II

0 Child Features

4 Contains

DB identifier Type Name
IPR002290 Domain Serine/threonine/dual specificity protein kinase, catalytic domain
IPR017892 Domain Protein kinase, C-terminal
IPR017441 Binding_site Protein kinase, ATP binding site
IPR008271 Active_site Serine/threonine-protein kinase, active site

1 Cross References


0 Found In

4 GO Annotations

GO Term Gene Name Organism
GO:0000287 IPR016239
GO:0004674 IPR016239
GO:0006468 IPR016239
GO:0035556 IPR016239

0 Parent Features

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID