Protein Domain : IPR016238

Type:  Family Name:  Ribosomal protein S6 kinase
Description:  This entry represents ribosomal protein S6 kinase. S6 kinase is part of the mammalian target of rapamycin (mTOR) pathway, which is a key regulator of cell growth via the regulation of protein synthesis. Both S6 kinase and eukaryotic initiation factor 4E-binding protein 1 (4EBP-1) are key mTOR effectors of cell growth []. S6 kinase specifically phosphorylates ribosomal protein S6 in response to insulin or several classes of mitogens. S6 kinase is activated by serine/threonine phosphorylation and protein kinase C, and is inactivated by type 2A phosphatase []. S6 kinase interacts with PPP1R9A/neurabin-1 []. Short Name:  Ribosomal_S6_kinase

0 Child Features

4 Contains

DB identifier Type Name
IPR002290 Domain Serine/threonine/dual specificity protein kinase, catalytic domain
IPR017892 Domain Protein kinase, C-terminal
IPR017441 Binding_site Protein kinase, ATP binding site
IPR008271 Active_site Serine/threonine-protein kinase, active site

1 Cross References

Identifier
PIRSF000605

0 Found In

3 GO Annotations

GO Term Gene Name Organism
GO:0004674 IPR016238
GO:0006468 IPR016238
GO:0007165 IPR016238

0 Parent Features

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            18092230
            17494629
            9653190