Protein Domain : IPR012233

Type:  Family Name:  Protein kinase C
Description:  This group represents protein kinase C (KPC), including zeta/iota types from mammals, protein kinase C-like 3 from round worms []and atypical protein kinase C (aPKC) from fruit flies []. Protein kinase C iota type (PRKCI) is a calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway [, , ]. It is an indirect co-regulator of the stress-activated transcription factor HSF1 and the heat shock response []. It has been linked to cancers [, ].Protein kinase C zeta type is a calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP) []. Short Name:  PKC

0 Child Features

7 Contains

DB identifier Type Name
IPR002290 Domain Serine/threonine/dual specificity protein kinase, catalytic domain
IPR000270 Domain PB1 domain
IPR002219 Domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR017892 Domain Protein kinase, C-terminal
IPR017441 Binding_site Protein kinase, ATP binding site
IPR008271 Active_site Serine/threonine-protein kinase, active site
IPR020454 Domain Diacylglycerol/phorbol-ester binding

2 Cross Referencess

Identifier
PTHR24357:SF60
PIRSF000554

0 Found In

2 GO Annotations

GO Term Gene Name Organism
GO:0004674 IPR012233
GO:0005524 IPR012233

0 Parent Features

0 Proteins

9 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10467349
            11257119
            20686607
            19738040
            22349825
            11544035
            11035106
            10995441
            9422779