Protein Domain : IPR017405

Type:  Family Name:  Citron Rho-interacting kinase
Description:  Citron Rho-interacting kinase (CRIK) is a dual specificity protein kinase, which catalyses the autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues []. It plays an important role in the regulation of cytokinesis and the development of the central nervous system. It is required for KIF14 localization to the central spindle and mid-body. It is also a putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. This protein occurs in at least two different isoforms: CRIK (about 240kDa), in which the kinase domain is followed by the sequence of Citron (a Rho/Rac binding protein); and CRIK-short kinase (CRIK-SK, about 54kDa), which consists mostly of the kinase domain. CRIK may fulfil more specialised functions in specific cell types []. Short Name:  Citron_Rho-interacting_kinase

0 Child Features

8 Contains

DB identifier Type Name
IPR002290 Domain Serine/threonine/dual specificity protein kinase, catalytic domain
IPR001849 Domain Pleckstrin homology domain
IPR011993 Domain Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
IPR001180 Domain Citron homology (CNH) domain
IPR002219 Domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR017892 Domain Protein kinase, C-terminal
IPR017441 Binding_site Protein kinase, ATP binding site
IPR008271 Active_site Serine/threonine-protein kinase, active site

2 Cross Referencess


0 Found In

0 GO Annotation

0 Parent Features

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID