Protein Domain : IPR016256

Type:  Family Name:  Serine/threonine-protein kinase Rad53
Description:  Rad53 is a protein kinase required for cell-cycle arrest in response to DNA damage. Rad53 controls the S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. It prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase Cdc5 []. Rad53 also seems to be involved in the phosphorylation of Rph1, a zinc finger protein that acts as a damage-responsive repressor of the photolyase gene Phr1 in Saccharomyces cerevisiae(Baker's yeast) []. The 2C type phosphatase, Ptc2, which is required for DNA checkpoint inactivation after double-strand breaks, appears to dephosphorylate Rad53 []. Short Name:  Ser/Thr_kinase_Rad53

0 Child Features

7 Contains

DB identifier Type Name
IPR000719 Domain Protein kinase domain
IPR011009 Domain Protein kinase-like domain
IPR002290 Domain Serine/threonine/dual specificity protein kinase, catalytic domain
IPR008984 Domain SMAD/FHA domain
IPR000253 Domain Forkhead-associated (FHA) domain
IPR017441 Binding_site Protein kinase, ATP binding site
IPR008271 Active_site Serine/threonine-protein kinase, active site

1 Cross References

Identifier
PIRSF000661

0 Found In

7 GO Annotations

GO Term Gene Name Organism
GO:0003688 IPR016256
GO:0004712 IPR016256
GO:0000077 IPR016256
GO:0006270 IPR016256
GO:0006281 IPR016256
GO:0009202 IPR016256
GO:0005634 IPR016256

0 Parent Features

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10550056
            11809875
            17325030