Protein Domain : IPR016248

Type:  Family Name:  Fibroblast growth factor receptor family
Description:  Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily.The FGFRs consist of an extracellular ligand-binding domain composed of three immunoglobulin-like domains (D1-D3), a single transmembrane helix domain, and an intracellular domain with tyrosine kinase activity []. The three immunoglobin(Ig)-like domains, D1, D2, and D3, present a stretch of acidic amino acids (knonw as the acid box) between D1 and D2. This acid box can participate in the regulation of FGF binding to the FGFR. Immunoglobulin-like domains D2 and D3 are sufficient for FGF binding. FGFR family members differ from one another in their ligand affinities and tissue distribution [, ]. Most FGFs can bind to several different FGFR subtypes. Indeed, FGF1 is sometimes referred to as the universal ligand, as it is capable of activating all of the different FGFRs []. However, there are some exceptions. For example, FGF7 only interacts with FGFR2 []and FGF18 was recently shown to only activate FGFR3 []. This entry represents the fibroblast growth factor receptor family. Short Name:  FGF_rcpt_fam

3 Child Features

DB identifier Type Name
IPR028174 Family Fibroblast growth factor receptor 1/4
IPR028175 Family Fibroblast growth factor receptor 2
IPR028176 Family Fibroblast growth factor receptor 3

10 Contains

DB identifier Type Name
IPR000719 Domain Protein kinase domain
IPR011009 Domain Protein kinase-like domain
IPR020635 Domain Tyrosine-protein kinase, catalytic domain
IPR001245 Domain Serine-threonine/tyrosine-protein kinase catalytic domain
IPR013783 Domain Immunoglobulin-like fold
IPR007110 Domain Immunoglobulin-like domain
IPR013098 Domain Immunoglobulin I-set
IPR003598 Domain Immunoglobulin subtype 2
IPR017441 Binding_site Protein kinase, ATP binding site
IPR008266 Active_site Tyrosine-protein kinase, active site

1 Cross References

Identifier
PIRSF000628

0 Found In

6 GO Annotations

GO Term Gene Name Organism
GO:0005007 IPR016248
GO:0005524 IPR016248
GO:0006468 IPR016248
GO:0008284 IPR016248
GO:0008543 IPR016248
GO:0016021 IPR016248

0 Parent Features

0 Proteins

22 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2549857
            7583099
            3072709
            11276432
            8652550
            1705486
            8760337
            23000357
            15689573
            10441498
            23108135
            23016864
            1649700
            11746231
            14745970
            8978613
            8663044
            16829530
            15781473
            16597617
            9212826
            18216218