Protein Domain : IPR017322

Type:  Family Name:  Receptor-interacting serine/threonine-protein kinase 2
Description:  This entry represents receptor-interacting serine/threonine-protein kinase 2 (RIP2), which functions in the phosphorylation () of its protein target. This enzyme activates pro-caspase-1 and pro-caspase-8, and it thought to potentiate CASP8-mediated apoptosis []. It also activates NF-kappa-B. RIP2 undergoes autophosphorylation; it is phosphorylated upon DNA damage, probably by ATM or ATR. Short Name:  Rcpt-int_Ser/Thr_kinase-2

0 Child Features

5 Contains

DB identifier Type Name
IPR000719 Domain Protein kinase domain
IPR011009 Domain Protein kinase-like domain
IPR011029 Domain Death-like domain
IPR001315 Domain CARD domain
IPR008271 Active_site Serine/threonine-protein kinase, active site

2 Cross Referencess


0 Found In

3 GO Annotations

GO Term Gene Name Organism
GO:0004674 IPR017322
GO:0043065 IPR017322
GO:0005737 IPR017322

0 Parent Features

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID