Protein Domain : IPR016257

Type:  Family Name:  Ephrin receptor type-A /type-B
Description:  This entry represents type A and type B ephrin receptors. Ephrin receptors (Ephs) are a group of receptor tyrosine kinases that are activated in response to binding ephrin ligands residing on adjacent cells []. This binding leads to contact-dependent bidirectional signaling into neighbouring cells []. Ephreceptors play critical roles in embryonic patterning [], neuronal targeting [], vascular development and adult neovascularization [].There are 10 EphA receptors and six EphB receptors, distinguished on sequence difference and binding preferences. They interact with the six glycosylphosphatidylinositol-linked ephrin-A ligands and the three transmembrane ephrin-B ligands, respectively []. Short Name:  Tyr_kinase_ephrin_rcpt

2 Child Features

DB identifier Type Name
IPR020691 Family Ephrin type-A receptor 8
IPR030602 Family Ephrin type-A receptor 4

13 Contains

DB identifier Type Name
IPR000719 Domain Protein kinase domain
IPR011009 Domain Protein kinase-like domain
IPR020635 Domain Tyrosine-protein kinase, catalytic domain
IPR001245 Domain Serine-threonine/tyrosine-protein kinase catalytic domain
IPR008979 Domain Galactose-binding domain-like
IPR001660 Domain Sterile alpha motif domain
IPR013761 Domain Sterile alpha motif/pointed domain
IPR003961 Domain Fibronectin type III
IPR011641 Domain Tyrosine-protein kinase ephrin type A/B receptor-like
IPR017441 Binding_site Protein kinase, ATP binding site
IPR008266 Active_site Tyrosine-protein kinase, active site
IPR001426 Conserved_site Tyrosine-protein kinase, receptor class V, conserved site
IPR001090 Domain Ephrin receptor ligand binding domain

1 Cross References


0 Found In

5 GO Annotations

GO Term Gene Name Organism
GO:0005003 IPR016257
GO:0005524 IPR016257
GO:0006468 IPR016257
GO:0007169 IPR016257
GO:0005887 IPR016257

0 Parent Features

0 Proteins

5 Publications

First Author Title Year Journal Volume Pages PubMed ID