Protein Domain : IPR015726

Type:  Family Name:  Serine/threonine protein kinase, striated muscle-specific
Description:  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Eukaryotic protein kinases [, , , ]are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases.This group of genes codes for 9-kb striated preferentially expressed gene (SPEG)alpha and the 11-kb SPEGbeta found in skeletal muscle and heart. SPEGbeta encodes a 355kDa protein that contains two serine/threonine kinase domains and is homologous to proteins of the myosin light chain kinase family. At least one kinase domain is active and capable of autophosphorylation []. Short Name:  Ser/Thr_kin_striated_muscle-sp

0 Child Features

10 Contains

DB identifier Type Name
IPR000719 Domain Protein kinase domain
IPR011009 Domain Protein kinase-like domain
IPR002290 Domain Serine/threonine/dual specificity protein kinase, catalytic domain
IPR013783 Domain Immunoglobulin-like fold
IPR003961 Domain Fibronectin type III
IPR007110 Domain Immunoglobulin-like domain
IPR013098 Domain Immunoglobulin I-set
IPR003598 Domain Immunoglobulin subtype 2
IPR017441 Binding_site Protein kinase, ATP binding site
IPR008271 Active_site Serine/threonine-protein kinase, active site

1 Cross References

Identifier
PTHR22964:SF9

0 Found In

3 GO Annotations

GO Term Gene Name Organism
GO:0004674 IPR015726
GO:0005524 IPR015726
GO:0006468 IPR015726

1 Parent Features

DB identifier Type Name
IPR020675 Family Myosin light chain kinase-related

0 Proteins

9 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3291115
            12368087
            12471243
            15078142
            15320712
            7768349
            1835513
            1956325
            10973969