Protein Domain : IPR015725

Type:  Family Name:  Telokin/Myosin light chain kinase
Description:  Smooth muscle myosin light chain kinase is a Ser/Thr protein kinase, contains 1 fibronectin type-III domain and 9 Ig-like C2-type (immunoglobulin-like) domains (based on similarity to other like proteins). These kinases phosphorylate a specific serine in the N terminus of a myosin light chain, which leads to the formation of calmodulin/MLCK signal transduction complexes, which allow selective transduction of calcium signals. In this reaction magnesium and calcium act as cofactors and the kinases are activated by phosphorylation on Tyr-478 (), (). Also included in this entry is telokin, an acidic protein identical to the C-terminal portion of myosin light chain kinase []. Short Name:  Telokin/Myosin_light_ch_kin

0 Child Features

10 Contains

DB identifier Type Name
IPR000719 Domain Protein kinase domain
IPR011009 Domain Protein kinase-like domain
IPR002290 Domain Serine/threonine/dual specificity protein kinase, catalytic domain
IPR013783 Domain Immunoglobulin-like fold
IPR003961 Domain Fibronectin type III
IPR007110 Domain Immunoglobulin-like domain
IPR013098 Domain Immunoglobulin I-set
IPR003598 Domain Immunoglobulin subtype 2
IPR017441 Binding_site Protein kinase, ATP binding site
IPR008271 Active_site Serine/threonine-protein kinase, active site

1 Cross References


0 Found In

0 GO Annotation

1 Parent Features

DB identifier Type Name
IPR020675 Family Myosin light chain kinase-related

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID