Protein Domain : IPR020691

Type:  Family Name:  Ephrin type-A receptor 8
Description:  Tyrosine-protein kinases can transfer a phosphate group from ATP to a tyrosine residue in a protein. These enzymes can be divided into two main groups []:Receptor tyrosine kinases (RTK), which are transmembrane proteins involved in signal transduction; they play key roles in growth, differentiation, metabolism, adhesion, motility, death and oncogenesis []. RTKs are composed of 3 domains: an extracellular domain (binds ligand), a transmembrane (TM) domain, and an intracellular catalytic domain (phosphorylates substrate). The TM domain plays an important role in the dimerisation process necessary for signal transduction []. Cytoplasmic / non-receptor tyrosine kinases, which act as regulatory proteins, playing key roles in cell differentiation, motility, proliferation, and survival. For example, the Src-family of protein-tyrosine kinases [].This entry represents ephrin type-A receptor 8, which is a receptor tyrosine kinase that binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighbouring cells []. Short Name:  EphrinA_rcpt8

0 Child Features

9 Contains

DB identifier Type Name
IPR000719 Domain Protein kinase domain
IPR011009 Domain Protein kinase-like domain
IPR020635 Domain Tyrosine-protein kinase, catalytic domain
IPR001245 Domain Serine-threonine/tyrosine-protein kinase catalytic domain
IPR009030 Domain Insulin-like growth factor binding protein, N-terminal
IPR000494 Domain Receptor L-domain
IPR006212 Repeat Furin-like repeat
IPR017441 Binding_site Protein kinase, ATP binding site
IPR006211 Domain Furin-like cysteine-rich domain

1 Cross References

Identifier
PTHR24416:SF274

0 Found In

2 GO Annotations

GO Term Gene Name Organism
GO:0004713 IPR020691
GO:0005004 IPR020691

1 Parent Features

DB identifier Type Name
IPR016257 Family Ephrin receptor type-A /type-B

0 Proteins

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12471243
            19275641
            16700535
            15845350
            12094214