Protein Domain : IPR008266

Type:  Active_site Name:  Tyrosine-protein kinase, active site
Description:  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichiacoli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Tyrosine-protein kinases can transfer a phosphate group from ATP to a tyrosine residue in a protein. These enzymes can be divided into two main groups []:Receptor tyrosine kinases (RTK), which are transmembrane proteins involved in signal transduction; they play key roles in growth, differentiation, metabolism, adhesion, motility, death and oncogenesis []. RTKs are composed of 3 domains: an extracellular domain (binds ligand), a transmembrane (TM) domain, and an intracellular catalytic domain (phosphorylates substrate). The TM domain plays an important role in the dimerisation process necessary for signal transduction []. Cytoplasmic / non-receptor tyrosine kinases, which act as regulatory proteins, playing key roles in cell differentiation, motility, proliferation, and survival. For example, the Src-family of protein-tyrosine kinases [].This entry represents the tyrosine protein kinase active site. It also matches a number of proteins belonging to the atypical serine/threonine protein kinase BUD32 family, which lack the conventional structural elements necessary for the substrate recognition and also lack the lysine residue that in all other serine/threonine kinases participates in the catalytic event. Short Name:  Tyr_kinase_AS

0 Child Features

0 Contains

1 Cross References

Identifier
PS00109

26 Found Ins

DB identifier Type Name
IPR000719 Domain Protein kinase domain
IPR011009 Domain Protein kinase-like domain
IPR020635 Domain Tyrosine-protein kinase, catalytic domain
IPR001245 Domain Serine-threonine/tyrosine-protein kinase catalytic domain
IPR022495 Family Serine/threonine-protein kinase Bud32
IPR016243 Family Tyrosine-protein kinase, CSF-1/PDGF receptor family
IPR009136 Family Vascular endothelial growth factor receptor 2 (VEGFR2)
IPR016246 Family Tyrosine-protein kinase, insulin-like receptor
IPR016251 Family Tyrosine-protein kinase, non-receptor Jak/Tyk2
IPR020775 Family Tyrosine-protein kinase, non-receptor Jak3
IPR020693 Family Tyrosine-protein kinase, non-receptor Jak2
IPR020776 Family Tyrosine-protein kinase, non-receptor Jak1
IPR020777 Family Tyrosine-protein kinase, neurotrophic receptor
IPR020446 Family Tyrosine-protein kinase, neurotrophic receptor, type 3
IPR020455 Family Tyrosine-protein kinase, neurotrophic receptor, type 2
IPR020461 Family Tyrosine-protein kinase, neurotrophic receptor, type 1
IPR016257 Family Ephrin receptor type-A /type-B
IPR009220 Family Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
IPR012234 Family Tyrosine-protein kinase, non-receptor SYK/ZAP-70
IPR015782 Family Dual specificity testis-specific protein kinase 1
IPR016248 Family Fibroblast growth factor receptor family
IPR016250 Family Tyrosine-protein kinase, Fes/Fps type
IPR016247 Family Tyrosine-protein kinase, receptor ROR
IPR016244 Family Tyrosine-protein kinase, HGF/MSP receptor
IPR016249 Family Tyrosine-protein kinase, Ret receptor
IPR016245 Family Tyrosine protein kinase, EGF/ERB/XmrK receptor

2 GO Annotations

GO Term Gene Name Organism
GO:0004672 IPR008266
GO:0006468 IPR008266

0 Parent Features

0 Proteins

8 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3291115
            12368087
            12471243
            15078142
            15320712
            19275641
            16700535
            15845350