Protein Domain : IPR009136

Type:  Family Name:  Vascular endothelial growth factor receptor 2 (VEGFR2)
Description:  Vascular endothelial growth factor (VEGF) is a potent and specific endothelial cell mitogen that regulates blood and lymphatic vessel development and homeostasis [, ]. EGFs are predominantly produced by endothelial, hematopoietic, and stromal cells in response to hypoxia and upon stimulation by growth factors such as transforming growth factor beta (TGFbeta), interleukins, or platelet-derived growth factors []. VEGFs specifically interact with one or several receptor tyrosine kinases, VEGF receptors, and with distinct co-receptors such as neuropilins or heparan sulphate glycosaminoglycans. The VEGF receptor family consists of three members, VEGFR1 (FLT1), VEGFR2 (KDR/FLK1) and VEGFR3 (FLT4) []. Among these receptors, VEGFR1 binds strongest to VEGF, VEGF2 binds more weakly, and VEGFR3 shows essentially no binding, although it does bind to other members of the VEGF family. VEGF receptors have a characteristic structure, with 7 Ig-like domains in the extracellular domain and a cytoplasmic tyrosine kinase domain with a long kinase insert region. VEGF receptors are activated upon ligand-mediated dimerisation.This entry represents VEGFR2 proteins. The tyrosine kinase domain of VEGFR2 tranduces signals for endothelial cells with a greater efficacy than VEGFR1. VEGFR2 expression in adult endothelial cells appears to account for most of the mitogenic and chemotactic effects of VEGF []. At the post-receptor level, activation of endothelial cells by VEGF leads to the autophosphorylation of VEGFR2 and the subsequent tyrosine phosphorylation of numerous downstream targets. Short Name:  VEGFR2_rcpt

0 Child Features

12 Contains

DB identifier Type Name
IPR000719 Domain Protein kinase domain
IPR011009 Domain Protein kinase-like domain
IPR020635 Domain Tyrosine-protein kinase, catalytic domain
IPR001245 Domain Serine-threonine/tyrosine-protein kinase catalytic domain
IPR013783 Domain Immunoglobulin-like fold
IPR007110 Domain Immunoglobulin-like domain
IPR003599 Domain Immunoglobulin subtype
IPR013098 Domain Immunoglobulin I-set
IPR003598 Domain Immunoglobulin subtype 2
IPR017441 Binding_site Protein kinase, ATP binding site
IPR001824 Conserved_site Tyrosine-protein kinase, receptor class III, conserved site
IPR008266 Active_site Tyrosine-protein kinase, active site

2 Cross Referencess

Identifier
PTHR24416:SF45
PR01834

0 Found In

6 GO Annotations

GO Term Gene Name Organism
GO:0005021 IPR009136
GO:0005524 IPR009136
GO:0019838 IPR009136
GO:0006468 IPR009136
GO:0048010 IPR009136
GO:0016021 IPR009136

0 Parent Features

0 Proteins

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2478587
            7526212
            7538139
            19290920
            7929439