Protein Domain : IPR002317

Type:  Family Name:  Serine-tRNA ligase, type1
Description:  Serine-tRNA ligase () exists as monomer and belongs to the aminoacyl-tRNA synthetase class IIa []. It catalyses the attachment of serine to tRNA (Ser). It is also able to aminoacylate tRNA (Sec) with serine, to form the misacylated tRNA L-seryl-tRNA (Sec), which will be further converted into selenocysteinyl-tRNA (Sec). The aminoacyl-tRNA synthetase (also known as aminoacyl-tRNA ligase) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These proteins differ widely in size and oligomeric state, and have limited sequence homology []. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric []. Class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet fold flanked by alpha-helices [], and are mostly dimeric or multimeric, containing at least three conserved regions [, , ]. However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, lysine, phenylalanine, proline, serine, and threonine belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c. Short Name:  Ser-tRNA-ligase_type_1

0 Child Features

4 Contains

DB identifier Type Name
IPR006195 Domain Aminoacyl-tRNA synthetase, class II
IPR015866 Domain Serine-tRNA synthetase, type1, N-terminal
IPR002314 Domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
IPR010978 Domain tRNA-binding arm

5 Cross Referencess

Identifier
PTHR11778
PR00981
PIRSF001529
TIGR00414
MF_00176

0 Found In

5 GO Annotations

GO Term Gene Name Organism
GO:0000166 IPR002317
GO:0004828 IPR002317
GO:0005524 IPR002317
GO:0006434 IPR002317
GO:0005737 IPR002317

0 Parent Features

480 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
231245 D8RCX7 PAC:15415292 Selaginella moellendorffii 419  
99251 D8RQJ4 PAC:15415093 Selaginella moellendorffii 456  
evm.model.supercontig_26.176 PAC:16415112 Carica papaya 450  
evm.model.supercontig_36.175 PAC:16418365 Carica papaya 520  
evm.model.supercontig_48.197 PAC:16420836 Carica papaya 386  
29788.m000334 B9SYP5 PAC:16808544 Ricinus communis 355  
29788.m000335 B9SYP6 PAC:16808545 Ricinus communis 119  
29827.m002630 B9S1P8 PAC:16810061 Ricinus communis 111  
29827.m002631 B9S1P9 PAC:16810062 Ricinus communis 250  
29827.m002633 B9S1Q1 PAC:16810064 Ricinus communis 447  
29908.m006072 B9RJP1 PAC:16812893 Ricinus communis 517  
29908.m006078 B9RJP7 PAC:16812899 Ricinus communis 380  
29908.m006079 B9RJP8 PAC:16812900 Ricinus communis 184  
30162.m001286 B9RKX9 PAC:16820963 Ricinus communis 447  
Cucsa.019310.1 A0A0A0KL58 PAC:16951850 Cucumis sativus 448  
Cucsa.019310.2 A0A0A0KL58 PAC:16951851 Cucumis sativus 448  
Cucsa.019310.3 PAC:16951852 Cucumis sativus 441  
Cucsa.019310.4 PAC:16951853 Cucumis sativus 382  
Cucsa.311610.1 PAC:16976724 Cucumis sativus 515  
GSVIVT01000041001 D7U1Z6 PAC:17816656 Vitis vinifera 447  
GSVIVT01029821001 D7TKV1 PAC:17836494 Vitis vinifera 168  
GSVIVT01004302001 PAC:17818981 Vitis vinifera 351  
orange1.1g043456m A0A067EWG5 PAC:18111794 Citrus sinensis 447  
orange1.1g016049m A0A067H0E1 PAC:18107683 Citrus sinensis 396  
AT1G11870.1 Q8RWT8 PAC:19650746 Arabidopsis thaliana 512  
AT5G27470.1 Q39230 PAC:19666235 Arabidopsis thaliana 451  
AT1G11870.3 F4IAJ4 PAC:19650747 Arabidopsis thaliana 402  
AT1G11870.2 Q8RWT8 PAC:19650745 Arabidopsis thaliana 514  
Thhalv10029181m V4LEU1 PAC:20198052 Eutrema salsugineum 258  
Thhalv10004203m V4K406 PAC:20199107 Eutrema salsugineum 451  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8364025
            8274143
            1852601
            2053131
            10673435
            2203971
            7540217