Protein Domain : IPR000104

Type:  Family Name:  Antifreeze protein, type I
Description:  Marine teleosts from polar oceans can be protected from freezing in icysea-water by serum antifreeze proteins (AFPs) or glycoproteins (AFGPs) []:these function by binding to, and preventing the growth of, ice crystalswithin the fish and depressing the non-equilibrium freezing point to below that of the melting point.Despite functional similarity, antifreeze proteins arestructurally diverse and include glycosylated and at least 3 non-glycosylated forms: the AFGP of nototheniids and cods are polymers of atripeptide repeat, Ala-Ala-Thr, with a disaccharide attached to thethreonine residue; type I AFPs are foundin flounder and sculpin; type II AFPs of sea-raven, smelt and herring areCys-rich proteins; and type III AFPs, found in eel pouts, are rich inbeta-structure. Non-homologous antifreeze proteins have also been identified in insects and plants [].Type I AFPs are Ala-rich, amphiphilic, alpha-helical proteins []. The ice-binding sites of all AFPs are relatively flat and hydrophobic and have an uninterupted section of alanines running the length of the approximately 16.5A helix repeat. Basedon the energy-minimised structure [], a model has been proposed todescribe the binding of the protein to ice crystals, whereby the proteinbinds to an ice nucleation structure, in a zipper-like fashion, viahydrogen bonding of the methyl-group of threonine side chains (with an 11-residue period) tooxygen atoms in the ice lattice. The growth of ice crystals is thusstopped, or retarded, and the freezing point depressed. The high lysince content of these peptides may serve to promote the solubility of these proteins. Short Name:  Antifreeze_1

0 Child Features

0 Contains

1 Cross References


0 Found In

3 GO Annotations

GO Term Gene Name Organism
GO:0050825 IPR000104
GO:0042309 IPR000104
GO:0050826 IPR000104

0 Parent Features

1185 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
150464 D8RW78 PAC:15414106 Selaginella moellendorffii 175  
evm.TU.contig_31071.3 PAC:16429928 Carica papaya 64  
evm.TU.contig_28899.3 PAC:16429648 Carica papaya 60  
evm.TU.contig_33123.1 PAC:16430208 Carica papaya 193  
evm.TU.contig_35121.1 PAC:16430588 Carica papaya 72  
evm.TU.contig_37291.1 PAC:16431014 Carica papaya 96  
evm.TU.contig_37916.1 PAC:16431101 Carica papaya 67  
evm.TU.contig_39242.1 PAC:16431307 Carica papaya 197  
evm.TU.contig_39530.1 PAC:16431351 Carica papaya 189  
evm.TU.contig_43087.1 PAC:16431825 Carica papaya 102  
evm.model.supercontig_1546.3 PAC:16409726 Carica papaya 60  
evm.model.supercontig_1618.2 PAC:16410229 Carica papaya 234  
evm.model.supercontig_18.152 PAC:16411296 Carica papaya 856  
evm.model.supercontig_313.2 PAC:16417274 Carica papaya 117  
evm.model.supercontig_431.2 PAC:16420066 Carica papaya 106  
44001.m000026 B9TMQ1 PAC:16827647 Ricinus communis 199  
49590.m000024 B9TI03 PAC:16828189 Ricinus communis 120  
GSVIVT01035053001 PAC:17840323 Vitis vinifera 427  
orange1.1g000178m PAC:18137007 Citrus sinensis 1914  
AT2G26140.1 A0A178VQU1 PAC:19642775 Arabidopsis thaliana 717  
AT1G73660.1 Q9C9U5 PAC:19651520 Arabidopsis thaliana 1030  
AT2G22840.1 O81001 PAC:19642241 Arabidopsis thaliana 530  
AT4G00390.1 O23063 PAC:19644769 Arabidopsis thaliana 364  
AT3G28840.1 Q058M7 PAC:19661250 Arabidopsis thaliana 391  
AT3G01120.1 A0A178VB36 PAC:19664003 Arabidopsis thaliana 563  
AT5G66000.1 Q9FKY2 PAC:19671359 Arabidopsis thaliana 215  
Thhalv10020394m V4NT73 PAC:20182141 Eutrema salsugineum 568  
Thhalv10018059m V4K9S3 PAC:20192111 Eutrema salsugineum 1030  
Thhalv10018149m V4KKL7 PAC:20192112 Eutrema salsugineum 781  
Ciclev10024213m PAC:20808875 Citrus clementina 1270  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID