Protein Domain : IPR004516

Type:  Family Name:  Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit
Description:  This entry represents histidine-tRNA ligase (HisS or HisRS) and its paralogue, ATP phosphoribosyltransferase regulatory subunit (HisZ). Despite the significant sequential and structural similarity, HisRS and HisZ have different functions []. HisRS is a class IIa aminoacyl-tRNA synthetase (ligase), while HisZ is a regulatory subunit of the hetero-octameric ATP phosphoribosyl transferase that regulate reactions initiating histidine biosynthesis [, ]. From the phylogenetic analysis, HisZ proteins form a monophyletic group that attaches outside the predominant bacterial HisRS clade []. HisZ are represented in a highly divergent set of bacteria (including an aquificale, cyanobacteria, firmicutes, and proteobacteria), but are missing from other bacteria, including mycrobacteria and certain proteobacteria []. It has been suggested that the absences of HisZ from bacteria are due to its loss during evolution []. Short Name:  HisRS/HisZ

2 Child Features

DB identifier Type Name
IPR015807 Family Histidine-tRNA ligase
IPR004517 Family ATP phosphoribosyltransferase regulatory subunit

3 Contains

DB identifier Type Name
IPR004154 Domain Anticodon-binding
IPR006195 Domain Aminoacyl-tRNA synthetase, class II
IPR002314 Domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)

2 Cross Referencess


0 Found In

1 GO Annotation

GO Term Gene Name Organism
GO:0005737 IPR004516

0 Parent Features

383 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
122255 D8SPU2 PAC:15419074 Selaginella moellendorffii 423  
evm.TU.contig_35476.1 PAC:16430654 Carica papaya 211  
evm.model.supercontig_1431.2 PAC:16409022 Carica papaya 778  
evm.model.supercontig_738.3 PAC:16425695 Carica papaya 280  
29757.m000724 B9SHN6 PAC:16807998 Ricinus communis 886  
30078.m002290 B9S0H3 PAC:16817401 Ricinus communis 503  
60536.m000014 B9TMT8 PAC:16829365 Ricinus communis 194  
Cucsa.088550.1 PAC:16957023 Cucumis sativus 879  
Cucsa.088550.2 PAC:16957024 Cucumis sativus 739  
Cucsa.124750.1 PAC:16961763 Cucumis sativus 507  
GSVIVT01036287001 D7TL75 PAC:17841262 Vitis vinifera 318  
GSVIVT01036288001 PAC:17841263 Vitis vinifera 574  
GSVIVT01025735001 PAC:17833670 Vitis vinifera 404  
orange1.1g011527m PAC:18099159 Citrus sinensis 484  
orange1.1g018556m PAC:18099160 Citrus sinensis 354  
orange1.1g022115m A0A067E4H6 PAC:18099161 Citrus sinensis 302  
orange1.1g024194m A0A067E438 PAC:18099162 Citrus sinensis 271  
orange1.1g003041m PAC:18129880 Citrus sinensis 854  
orange1.1g003117m PAC:18129881 Citrus sinensis 846  
AT3G02760.1 F4IYF8 PAC:19664037 Arabidopsis thaliana 883  
AT5G03406.1 F4KFB0 PAC:19668640 Arabidopsis thaliana 263  
AT3G46100.1 O82413 PAC:19660507 Arabidopsis thaliana 486  
Thhalv10001912m V4MCC7 PAC:20200742 Eutrema salsugineum 771  
Thhalv10020033m V4MBI7 PAC:20183209 Eutrema salsugineum 876  
Thhalv10013386m V4NC95 PAC:20206523 Eutrema salsugineum 488  
Thhalv10014016m V4L003 PAC:20206524 Eutrema salsugineum 342  
Ciclev10013364m V4UQ20 PAC:20799162 Citrus clementina 309  
Ciclev10013920m V4SLQ2 PAC:20798467 Citrus clementina 69  
Ciclev10018820m V4TNC4 PAC:20807070 Citrus clementina 866  
Ciclev10013900m V4SLQ2 PAC:20798468 Citrus clementina 69  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID