Protein Domain : IPR017892

Type:  Domain Name:  Protein kinase, C-terminal
Description:  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].This domain is found in a large variety of protein kinases with different functions and dependencies. Protein kinase C, for example, is a calcium-activated, phospholipid-dependent serine- and threonine-specific enzyme. It is activated by diacylglycerol which, in turn, phosphorylates a range of cellular proteins. This domain is most often found associated with . Short Name:  Pkinase_C

0 Child Features

0 Contains

1 Cross References

Identifier
PF00433

7 Found Ins

DB identifier Type Name
IPR020684 Family Rho-associated protein kinase 1/2
IPR014376 Family Protein kinase C, delta/epsilon/eta/theta types
IPR017405 Family Citron Rho-interacting kinase
IPR012233 Family Protein kinase C
IPR016238 Family Ribosomal protein S6 kinase
IPR016239 Family Ribosomal protein S6 kinase II
IPR014375 Family Protein kinase C, alpha/beta/gamma types

3 GO Annotations

GO Term Gene Name Organism
GO:0004674 IPR017892
GO:0005524 IPR017892
GO:0006468 IPR017892

1 Parent Features

DB identifier Type Name
IPR000961 Domain AGC-kinase, C-terminal

1185 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
117203 D8SHG2 PAC:15403880 Selaginella moellendorffii 489  
179756 D8SHG4 PAC:15412360 Selaginella moellendorffii 527  
91298 D8REX3 PAC:15414173 Selaginella moellendorffii 530  
evm.model.supercontig_165.21 PAC:16410361 Carica papaya 516  
evm.model.supercontig_28.121 PAC:16415862 Carica papaya 151  
evm.model.supercontig_49.23 PAC:16421090 Carica papaya 522  
evm.model.supercontig_678.1 PAC:16424802 Carica papaya 547  
evm.model.supercontig_1116.3 PAC:16405900 Carica papaya 155  
28492.m000480 B9SV26 PAC:16800960 Ricinus communis 575  
29739.m003581 B9RQT0 PAC:16807361 Ricinus communis 623  
29912.m005311 B9RK53 PAC:16813190 Ricinus communis 492  
30147.m014030 B9R905 PAC:16820045 Ricinus communis 297  
30170.m013870 B9R7B8 PAC:16821714 Ricinus communis 522  
Cucsa.383560.1 A0A0A0LKM0 PAC:16982408 Cucumis sativus 551  
Cucsa.383560.2 A0A0A0LKM0 PAC:16982409 Cucumis sativus 551  
Cucsa.388210.1 A0A0A0K5D9 PAC:16982820 Cucumis sativus 557  
Cucsa.396130.1 A0A0A0LNF7 PAC:16983473 Cucumis sativus 523  
Cucsa.155420.1 PAC:16964771 Cucumis sativus 490  
Cucsa.197330.1 PAC:16968405 Cucumis sativus 486  
Cucsa.299600.1 PAC:16975519 Cucumis sativus 500  
Cucsa.299600.2 PAC:16975520 Cucumis sativus 386  
Cucsa.299600.3 PAC:16975521 Cucumis sativus 386  
Cucsa.299600.9 PAC:16975527 Cucumis sativus 359  
GSVIVT01007841001 PAC:17820565 Vitis vinifera 296  
GSVIVT01009489001 E0CPV2 PAC:17821890 Vitis vinifera 525  
GSVIVT01021759001 D7TKR6 PAC:17830773 Vitis vinifera 564  
GSVIVT01015159001 D7TCL5 PAC:17825959 Vitis vinifera 498  
GSVIVT01035418001 PAC:17840576 Vitis vinifera 487  
GSVIVT01027833001 D7SZI1 PAC:17835117 Vitis vinifera 550  
GSVIVT01028361001 PAC:17835525 Vitis vinifera 526  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3291115
            12368087
            12471243
            15078142
            15320712