| Type: | Domain | Name: | Protein kinase, C-terminal |
| Description: | Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].This domain is found in a large variety of protein kinases with different functions and dependencies. Protein kinase C, for example, is a calcium-activated, phospholipid-dependent serine- and threonine-specific enzyme. It is activated by diacylglycerol which, in turn, phosphorylates a range of cellular proteins. This domain is most often found associated with . | Short Name: | Pkinase_C |
| DB identifier | Type | Name |
|---|---|---|
| IPR020684 | Family | Rho-associated protein kinase 1/2 |
| IPR014376 | Family | Protein kinase C, delta/epsilon/eta/theta types |
| IPR017405 | Family | Citron Rho-interacting kinase |
| IPR012233 | Family | Protein kinase C |
| IPR016238 | Family | Ribosomal protein S6 kinase |
| IPR016239 | Family | Ribosomal protein S6 kinase II |
| IPR014375 | Family | Protein kinase C, alpha/beta/gamma types |
| GO Term | Gene Name | Organism |
|---|---|---|
| GO:0004674 | IPR017892 | |
| GO:0005524 | IPR017892 | |
| GO:0006468 | IPR017892 |
