Protein Domain : IPR013543

Type:  Domain Name:  Calcium/calmodulin-dependent protein kinase II, association-domain
Description:  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].This domain is found at the C terminus of the Calcium/calmodulin dependent protein kinases II (CaMKII). These proteins also have a Ser/Thr protein kinase domain () at their N terminus []. The function of the CaMKII association domain is the assembly of the single proteins into large (8 to 14 subunits) multimers []and is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Short Name:  Ca/CaM-dep_prot_kinase-assoc

0 Child Features

0 Contains

1 Cross References

Identifier
PF08332

2 Found Ins

DB identifier Type Name
IPR020636 Family Calcium/calmodulin-dependent/calcium-dependent protein kinase
IPR016887 Family Uncharacterised conserved protein UCP028470, steroid isomerase-related

3 GO Annotations

GO Term Gene Name Organism
GO:0004683 IPR013543
GO:0005516 IPR013543
GO:0006468 IPR013543

0 Parent Features

20 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
90245 D8RCF6 PAC:15411115 Selaginella moellendorffii 150  
Cre16.g661750.t1.2 PAC:30778252 Chlamydomonas reinhardtii 354  
Cre16.g661850.t1.1 PAC:30776788 Chlamydomonas reinhardtii 379  
Sphfalx0017s0039.1.p PAC:32620232 Sphagnum fallax 432  
Pp3c2_32010V3.5.p PAC:32934155 Physcomitrella patens 355  
Pp3c2_32010V3.7.p PAC:32934157 Physcomitrella patens 355  
Pp3c2_32010V3.6.p PAC:32934156 Physcomitrella patens 355  
Pp3c2_32010V3.4.p PAC:32934154 Physcomitrella patens 355  
Pp3c2_32010V3.3.p PAC:32934153 Physcomitrella patens 355  
Pp3c2_32010V3.2.p PAC:32934152 Physcomitrella patens 355  
Pp3c2_32010V3.1.p PAC:32934151 Physcomitrella patens 355  
Pp3c1_4090V3.6.p PAC:32968571 Physcomitrella patens 274  
Pp3c1_4090V3.7.p PAC:32968570 Physcomitrella patens 356  
Pp3c1_4090V3.4.p PAC:32968568 Physcomitrella patens 356  
Pp3c1_4090V3.3.p PAC:32968567 Physcomitrella patens 356  
Pp3c1_4090V3.2.p PAC:32968566 Physcomitrella patens 356  
Pp3c1_4090V3.1.p PAC:32968565 Physcomitrella patens 356  
Pp3c1_4090V3.5.p PAC:32968569 Physcomitrella patens 356  
Mapoly0021s0126.1.p PAC:33007837 Marchantia polymorpha 427  
Dusal.0575s00002.1.p PAC:33197411 Dunaliella salina 362  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3291115
            12368087
            12471243
            15078142
            15320712
            14993460
            12603201