Protein Domain : IPR000687

Type:  Domain Name:  RIO kinase
Description:  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].This entry represents RIO kinase, they exhibit little sequence similarity with eukaryotic protein kinases, and are classified as atypical protein kinases []. The conformation of ATP when bound to the RIO kinases is unique when compared with ePKs, such as serine/threonine kinases or the insulin receptor tyrosine kinase, suggesting that the detailed mechanism by which the catalytic aspartate of RIO kinases participates in phosphoryl transfer may not be identical to that employed in known serine/threonine ePKs. Representatives of the RIO family are present in organisms varying from Archaea to humans, although the RIO3 proteins have only been identified in multicellular eukaryotes, to date. Yeast Rio1 and Rio2 proteins are required for proper cell cycle progression and chromosome maintenance, and are necessary for survival of the cells. These proteins are involved in the processing of 20 S pre-rRNA via late 18 S rRNA processing. Short Name:  RIO_kinase

0 Child Features

1 Contains

DB identifier Type Name
IPR018935 Conserved_site RIO kinase, conserved site

1 Cross References


2 Found Ins

DB identifier Type Name
IPR017407 Family Serine/threonine-protein kinase Rio1
IPR017406 Family Serine/threonine-protein kinase Rio3

2 GO Annotations

GO Term Gene Name Organism
GO:0004674 IPR000687
GO:0005524 IPR000687

1 Parent Features

DB identifier Type Name
IPR011009 Domain Protein kinase-like domain

439 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
427273 D8SZ29 PAC:15409561 Selaginella moellendorffii 380  
91326 D8RDZ8 PAC:15414773 Selaginella moellendorffii 502  
153166 D8S7A2 PAC:15420498 Selaginella moellendorffii 331  
evm.model.supercontig_250.13 PAC:16414903 Carica papaya 547  
evm.model.supercontig_9.237 PAC:16428132 Carica papaya 430  
29093.m000080 B9T518 PAC:16802291 Ricinus communis 470  
30147.m014509 B9RAG3 PAC:16820517 Ricinus communis 334  
Cucsa.122400.1 A0A0A0LQN2 PAC:16961475 Cucumis sativus 562  
Cucsa.320350.1 A0A0A0L5Q5 PAC:16977337 Cucumis sativus 476  
Cucsa.320350.2 PAC:16977338 Cucumis sativus 429  
GSVIVT01008542001 D7SGY7 PAC:17821129 Vitis vinifera 795  
GSVIVT01038269001 D7T2P0 PAC:17842637 Vitis vinifera 467  
orange1.1g013290m A0A067FGP4 PAC:18108629 Citrus sinensis 446  
orange1.1g012048m A0A067F5K3 PAC:18108627 Citrus sinensis 472  
orange1.1g012042m A0A067F5K3 PAC:18108628 Citrus sinensis 472  
orange1.1g014939m A0A067F904 PAC:18108630 Citrus sinensis 415  
orange1.1g017458m A0A067FHF8 PAC:18108631 Citrus sinensis 371  
orange1.1g011300m A0A067EP71 PAC:18123592 Citrus sinensis 489  
orange1.1g015953m A0A067ENC7 PAC:18123593 Citrus sinensis 397  
orange1.1g020269m A0A067ECB6 PAC:18123594 Citrus sinensis 328  
AT5G37350.2 F4K748 PAC:19671838 Arabidopsis thaliana 385  
AT5G37350.1 Q9FHT0 PAC:19671837 Arabidopsis thaliana 531  
AT3G51270.2 F4J3B0 PAC:19662596 Arabidopsis thaliana 458  
AT3G51270.1 F4J3A9 PAC:19662595 Arabidopsis thaliana 461  
AT2G24990.1 Q9SK34 PAC:19642232 Arabidopsis thaliana 537  
Thhalv10000120m V4LRV8 PAC:20208485 Eutrema salsugineum 534  
Thhalv10010355m V4LNP3 PAC:20207737 Eutrema salsugineum 463  
Thhalv10010356m V4LNP3 PAC:20207738 Eutrema salsugineum 463  
Ciclev10008692m V4WFY0 PAC:20793345 Citrus clementina 371  
Ciclev10008178m V4USM3 PAC:20793343 Citrus clementina 472  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID