Protein Domain : IPR000157

Type:  Domain Name:  Toll/interleukin-1 receptor homology (TIR) domain
Description:  Toll proteins or Toll-like receptors (TLRs) and the interleukin-1 receptor(IL-1R) superfamily are both involved in innate antibacterial and antifungalimmunity in insects as well as in mammals. These receptors share a conservedcytoplasmic domain of approximately 200 amino acids, known as the Toll/IL-1Rhomologous region (TIR). The similarity between TLRs and IL-1Rs is notrestricted to sequence homology since these proteins also share a similarsignaling pathway. They both induce the activation of a Rel type transcriptionfactor via an adaptor protein and a protein kinase []. Interestingly, MyD88,a cytoplasmic adaptor protein found in mammals, contains a TIR domainassociated to a DEATH domain [, , ]. Besides the mammalianand Drosophila proteins, a TIR domain is also found in a number of plantcytoplasmic proteins implicated in host defense [Van der Biezen E.A., Jones J.D., Trends Biochem. Sci. 23:454-456(1998)].Site directed mutagenesis and deletion analysis have shown that the TIR domain is essential for Toll and IL-1R activities. Sequence analysis have revealedthe presence of three highly conserved regions among the different members ofthe family: box 1 (FDAFISY), box 2 (GYKLC-RD-PG), and box 3 (a conserved Wsurrounded by basic residues). It has been proposed that boxes 1 and 2 areinvolved in the binding of proteins involved in signalling, whereas box 3 isprimarily involved in directing localization of receptor, perhaps throughinteractions with cytoskeletal elements [].Resolution of the crystal structures of the TIR domains of human Toll-likereceptors 1 and 2 has shown that they contain a central five-stranded parallelbeta-sheet that is surrounded by a total of five helices on both sides []. Short Name:  TIR_dom

0 Child Features

0 Contains

6 Cross Referencess


4 Found Ins

DB identifier Type Name
IPR017241 Family Toll-like receptor
IPR017279 Family Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap
IPR017281 Family Myeloid differentiation primary response protein MyD88
IPR004076 Family Interleukin-1 receptor type 1

2 GO Annotations

GO Term Gene Name Organism
GO:0005515 IPR000157
GO:0007165 IPR000157

0 Parent Features

1185 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
444153 D8S7E4 PAC:15414463 Selaginella moellendorffii 159  
131977 D8T4X5 PAC:15406345 Selaginella moellendorffii 214  
421974 D8SGY6 PAC:15419719 Selaginella moellendorffii 334  
evm.model.supercontig_12.63 PAC:16406904 Carica papaya 972  
evm.model.supercontig_17.221 PAC:16410724 Carica papaya 144  
evm.model.supercontig_170.7 PAC:16410890 Carica papaya 428  
evm.model.supercontig_2.253 PAC:16412623 Carica papaya 1063  
evm.model.supercontig_2.255 PAC:16412625 Carica papaya 1284  
evm.model.supercontig_2.256 PAC:16412626 Carica papaya 1283  
evm.model.supercontig_214.13 PAC:16413719 Carica papaya 1001  
evm.model.supercontig_234.7 PAC:16414401 Carica papaya 205  
evm.model.supercontig_234.9 PAC:16414403 Carica papaya 1080  
evm.model.supercontig_245.4 PAC:16414617 Carica papaya 531  
evm.model.supercontig_27.17 PAC:16415545 Carica papaya 1200  
evm.model.supercontig_27.176 PAC:16415552 Carica papaya 122  
evm.model.supercontig_27.79 PAC:16415702 Carica papaya 195  
evm.model.supercontig_4.82 PAC:16419381 Carica papaya 1122  
evm.model.supercontig_4.96 PAC:16419396 Carica papaya 171  
evm.model.supercontig_80.91 PAC:16426820 Carica papaya 200  
28108.m000142 B9T1A0 PAC:16799949 Ricinus communis 191  
28490.m000028 B9T880 PAC:16800942 Ricinus communis 597  
28525.m000274 B9SXA8 PAC:16801046 Ricinus communis 1116  
28657.m000381 B9T0I7 PAC:16801438 Ricinus communis 642  
28660.m000194 B9SX40 PAC:16801473 Ricinus communis 833  
29662.m000467 B9SNY0 PAC:16805109 Ricinus communis 908  
29662.m000469 B9SNY2 PAC:16805111 Ricinus communis 468  
29662.m000471 B9SNY4 PAC:16805113 Ricinus communis 153  
29666.m001476 B9SAH3 PAC:16805170 Ricinus communis 210  
29736.m002081 B9S2G3 PAC:16807186 Ricinus communis 1349  
29747.m001050 B9SFT6 PAC:16807716 Ricinus communis 673  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID